314268-06-9

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 314268-44-5 1,1-dimethylethyl [1-[4-(cyanoacetyl)phenyl]-1-methylethyl]carbamate 
• 314268-43-4 1,1-dimethylethyl[1-[4-(5-isoxazolyl)phenyl]-1-methylethyl]carbamate 
• 314267-84-0 1-[4-(5-isoxazolyl)phenyl]-1-methylethylamine 
• 314267-82-8 1-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2-cyano-3-dimethyl-aminopropen-1-one 

Downstream Products

• 314268-08-1 1,1-dimethylethyl[1-[4-[5-cyano-2-[[4-[2-(4-morpholinyl)ethyl]phenyl]-amino]-4-pyrimidinyl]phenyl]-1-methylethyl]carbamate 
• 314268-09-2 C₃₂H₃₇N₇O₂ 

Relevant academic research and scientific papers

4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

A novel series of 4-aryl-5-cyano-2-aminopyrimidines were synthesized and found to have potent VEGF-R2 kinase inhibitory activity. Structure-activity relationships were investigated and compound 14a was shown to be efficacious in a mouse model of corneal neovascularization.