314270-27-4

Upstream product

• 314270-36-5 (R)-2-[2-((S)-2-Triphenylsilanyloxy-propyl)-thiazol-4-yl]-propan-1-ol 
• 314270-26-3 4-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-2-((S)-2-triphenylsilanyloxy-propyl)-thiazole 
• 308240-79-1 (S)-1-bromo-4-(tert-butyldimethylsilanyloxy)-3-methylbutan-2-one 
• 314270-37-6 (S)-3-[2-((S)-2-Triphenylsilanyloxy-propyl)-thiazol-4-yl]-butyronitrile 

Downstream Products

• 314270-28-5 (E)-(S)-5-[2-((S)-2-Triphenylsilanyloxy-propyl)-thiazol-4-yl]-hex-2-enoic acid (E)-4-iodo-3-methyl-but-3-enyl ester 

Relevant academic research and scientific papers

Towards pateamine. A comparison of palladium-catalysed sp2-sp2 coupling protocols to polyene macrolides

The Heck reaction is compared with the Stille reaction in the elaboration of the Z-2,E-4 diene acrylate unit in the model compounds 2a and 2b as an approach to the polyene macrolide core of the immunosuppressant agent pateamine 1 produced by the marine sponge Mycale sp.