314271-23-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 16133-49-6 5-methoxy-2-nitroaniline 

Downstream Products

• 314271-24-4 N-(2-amino-5-methoxyphenyl)-N-methylcarbamic acid t-butyl ester 
• 185428-55-1 (5-methoxy-2-nitro-phenyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Intermediates for the synthesis of benzimidazole derivatives and a process for the preparation thereof

This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof, 1wherein R1 is C1-C6 alkyl, C1-C6 alkoxyl, etc., R2 is C1-C6 alkyl, and R3 is hydrogen or a protecting group, which exhibits excellent hyopoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.

INTERMEDIATES FOR THE SYNTHESIS OF BENZIMIDAZOLE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF

This invention provides a process for the preparation of a benzimidazole derivative (I) or a pharmaceutically acceptable salt thereof,wherein R1is C1-C6alkyl, C1-C6alkoxyl, etc., R2is C1-C6alkyl, and R3is hydrogen or a protecting group, which exhibits excellent hypoglycemic action, said process comprising condensation of an amine derivative (III) with a carboxylic acid derivatives (II) to afford a compound (IV), followed by cyclization of compound (IV) in the presence of an acid.