314283-05-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-[(2-nitrophenyl)sulfonyl]piperidine is used as a reagent in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique chemical structure and properties make it suitable for the development of new drugs and pesticides.
Used in Biochemical and Pharmacological Research:
NPS-pip is employed as a potent and selective inhibitor of various enzymes, which is crucial for understanding enzyme functions and developing targeted therapies. Its inhibitory effects on enzymes make it a valuable tool in biochemical and pharmacological research, aiding in the discovery of new drug candidates and the study of enzyme mechanisms.

Upstream product

• 110-89-4 piperidine 
• 880771-84-6 2,3-indoledione 3-oxime O-(2-nitrobenzene)sulfonate 
• 880771-85-7 5-bromo-2,3-indoledione 3-oxime O-(2-nitrobenzene)sulfonate 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 5906-99-0 2-nitrobenzenesulfonyl hydrazide 
• 1411933-76-0 N-{4-methyl-2-[(2E)-1-methylbut-2-en-1-yl]-phenyl}-2-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

Metal-free synthesis of sulfonamides via iodine-catalyzed oxidative coupling of sulfonyl hydrazides and amines

A novel, rapid, and environmentally-friendly protocol for the synthesis of sulfonamides using iodine as catalyst under solvent-free conditions is described. This method involves the oxidative coupling of sulfonyl hydrazides and amines in the presence of catalytic amount of iodine using TBHP as oxidant. This protocol does not require purification techniques such as column chromatography and recrystalization.

Reactions of N-and C-alkenylanilines: X.* Synthesis of 2-vinyldihydroindoles from 4-methyl-2-(pent-3-en-2-yl)aniline

2-(1-Iodoethyl)-3,5-dimethyl-1-(4-methylphenylsulfonyl)-2, 3-dihydro-1H-indole reacted with pyridine, piperidine, N-alkylpiperidines, and dimethylformamide to give dehydrohalogenation and halogen substitution products whose ratio depended on the reagent s

Acylating and arylsulfonylating ability of O-derivatives of isatin 3-oximes

O-Acyl and O-arylsulfonyl derivatives of isatin 3-oximes have been synthesized and their interaction with alcohols and amines has been investigated. It was established that none of the esters of 1-substituted isatin 3-oximes reacted with the indicated nucleophiles. 1-Unsubstituted O-aryl and O-arylsulfonyl derivatives react with amines as acylating agents even at room temperature, but O-acetyl derivatives only on heating. Acylamides or arylsulfamides respectively are formed in this way. O-Acyl derivatives do not react with alcohols at room temperature. Only O-benzoyl derivatives form ethyl benzoate on heating in ethanol. A comparative analysis of mass spectrometric data on the processes of acylation and arylsulfonylation is given.