314285-39-7

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4-(4-METHYL-PIPERIDINE-1-SULFONYL)-PHENYLAMINE is used as a chemical compound with potential applications in pharmaceutical research and drug development for its wide range of biological activities, including antimicrobial, antiviral, and antiparasitic properties.
Used as a Building Block for Synthesis:
4-(4-METHYL-PIPERIDINE-1-SULFONYL)-PHENYLAMINE is used as a building block for the synthesis of other compounds with similar pharmacological effects, contributing to the development of new therapeutic agents.

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 321970-52-9 4-((4-methylpiperidin-1-yl)sulfonyl)aniline 
• 626-58-4 4-methylpiperidin 
• 303137-43-1 N-[4-(4-methylpiperidin-1-sulfonyl)phenyl]acetamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 1363144-59-5 3-{4-[(4-methylpiperidin-1-yl)sulfonyl]phenyl}-1-(pyridin-3-ylmethyl)urea 
• 1182564-94-8 C₁₈H₂₁N₃O₃S 
• 1000417-71-9 2-amino-6-[4-(4-methylpiperidin-1-sulfonyl)phenylamino]-5-nitro-3H-pyrimidin-4-one 

Relevant academic research and scientific papers

Design, synthesis and in vitro antitumor evaluation of novel diaryl urea derivatives bearing sulfonamide moiety

A novel series of diaryl urea derivatives bearing sulfonamide moiety have been designed and synthesized. Their in vitro antitumor effect against human cancer cell lines MX-1, A375, HepG2, Ketr3 and HT-29 was screened and evaluated by the standard MTT assa

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu 4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

Herein we disclose the synthesis and SAR of a series of 4-(phenylsulfamoyl)phenylacetamide compounds as mGlu4 positive allosteric modulators (PAMs) that were identified via a functional HTS. An iterative parallel approach to these compounds culminated in the discovery of VU0364439 (11) which represents the most potent (19.8 nM) mGlu4 PAM reported to date.

Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex

Measles virus (MV) is one of the most infectious pathogens known. In spite of the existence of a vaccine, approximately 350000 deaths/year result from MV or associated complications. Antimeasles compounds could conceivably diminish these statistics and pr

Synthesis and antimicrobial evaluation of guanylsulfonamides

A series of guanylsulfonamides, 2-amino-9-[2-substituted-4-(4-substituted piperidin-1-sulfonyl)phenyl]-1,9-dihydropurin-6-ones, was synthesized by adopting reductive aminoformylation of 2-amino-5-nitro-6-[4-(piperidin-1-sulfonyl)phenylamino]-3H-pyrimidin- 4-one and subsequent intramolecular ring condensation as key steps. All the guanylsulfonamides were assayed for their in vitro antibacterial activities against Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis, and their antifungal activities against Aspergillus flavus, Aspergillus niger, and Candida albicans. Of the guanylsulfonamides, 13e and 13f displayed better antibacterial activities than that of Norfloxacin against the bacterial strains S. aureus and S. faecalis except 13f against S. faecalis, which exhibited the activity similar to that of Norfloxacin. Against the fungal strains A. flavus and A. niger, 13g and 13h showed similar activities to that of Griseoflavin-16 except 13h against A. niger, which displayed a profound drop in the activity compared to that of Griseoflavin-16. The remarkable inhibition of the growth of the bacterial and fungal strains makes these substances promising microbial agents.