3144-89-6Relevant articles and documents
Isomerization of 4-arylamino-1,2-naphthoquinones to 2-arylamino-1,4-naphthoquinones
Gornostaev,Rukovets,Lavrikova,Khalyavina, Yu. G.,Stashina
, p. 1007 - 1010 (2017)
4-Arylamino-1,2-naphthoquinones isomerize into 2-arylamino-1,4-naphthoquinones upon refluxing in acetic acid. The isomerization follows two routes via intermediate 2-hydroxy-1,4-naphthoquinone and 2-arylamino-1,4-naphthoquinone 4-N-arylimines.
Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects
Banerjee, Uttam C.,Chaudhary, Hiteshkumar,Daniel, Divine P,Das, Biswajit,Grewal, Preeti,Guchhait, Sankar K.,Kumar, Gulshan,Kundu, Chanakya N.,Nayak, Deepika,Paul, Subarno,Sisodiya, Shailendra
supporting information, (2021/08/12)
Two series of (hetero)arylamino-naphthoquinones and benzo-fused carbazolequinones were considered for study with the rationale that related structural motifs are present in numerous drugs, clinical trial agents, natural products and hTopoIIα inhibitors. Total 42 compounds were synthesized by reactions including dehydrogenative C–N and Pd-catalyzed C–C bond forming transformations. These compounds were screened against numerous cancer cells including highly metastatic one (MCF-7, MDA-MB-231, H-357 and HEK293T), and normal cells (MCF 10A). Some of the active compounds were evaluated for clonogenic cell survival and apoptotic effects in cancer cells (DAPI nuclear staining, Comet assay, Annexin-V-FITC/PI dual staining, flow cytometry, and western blot analysis with relevant proteins). All compounds were tested for hTopoIIα inhibitory activity. The investigated series compounds showed important properties like significant apoptotic antiproliferation in cancer cells with cell cycle arrest at S-phase and downregulation of NF- κβ signaling cascade, relatively less cytotoxicity to normal cells, and hTopoIIα inhibition with more efficiency compared to an anticancer drug etoposide.
Synthesis of novel substituted methoxybenzo[2,3-b]carbazole derivatives via C-H functionalization. Experimental and theoretical characterization of their photophysical properties
Lisboa, Cinthia da Silva,de Lucas, Nanci C.,Garden, Simon J.
, p. 618 - 632 (2016/08/23)
The novel, highly blue, fluorescent N-methyl-6,11-dimethoxybenzo[2,3-b]carbazole derivatives were prepared by oxidative coupling of anilines with naphthoquinone followed by palladium catalyzed oxidative [Formula presented] functionalization and a one pot
