31456-70-9Relevant academic research and scientific papers
Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity
Lenzen, Karst,Planchestainer, Matteo,Feller, Isabelle,Padrosa, David Roura,Paradisi, Francesca,Albrecht, Martin
, p. 9068 - 9071 (2021)
Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placedviasolid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes.
