31462-54-1

Usage

Chemical Properties

Light yellow powder

InChI:InChI=1/C4H3IN2/c5-4-6-2-1-3-7-4/h1-3H

Upstream product

• 1722-12-9 2-chloropyrimidine 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 129973-57-5 1-(Pyrimidin-2-yl)-2-(2-nitrophenyl)ethyne 
• 34671-83-5 2,2'-Bipyrimidine 
• 1236567-72-8 N,N-dihexyl-4-[5-(pyrimidine-2-yl) thiophene-2-yl] aniline 
• 7431-45-0 2-phenylpyrimidine 
• 40828-51-1 2-hydroxy-5-pyrimidinesulfonic acid 
• 164296-40-6 diethyl 2-(Pyrimidin-2-yl)malonate 
• 5621-02-3 2-(dimethylamino)pyrimidine 
• 134914-65-1 2-(1H-imidazol-1-yl)pyrimidine 
• 116470-67-8 2-(trifluoromethyl)pyrimidine 
• 1432051-95-0 trans-3-((tert-butyldimethylsilyl)oxy)-3-methyl-1-((4-(trifluoromethoxy)-phenyl)cyclobutyl)(pyrimidin-2-yl)methanol 
• 1390618-67-3 4-(1-pyrimidin-2-yl-pyrrolidin-3-ylamino)-benzoic acid methyl ester 

Relevant academic research and scientific papers

CHEMICAL PROCESS

The present invention provides, inter alia, a process for producing a compound of formula (I) wherein the substituents are as defined in claim 1. The present invention further provides intermediate compounds utilised in said process, and methods for producing said intermediate compounds.

Cobalt-Catalyzed Preparation of N -Heterocyclic Organozinc Reagents from the Corresponding Heteroaryl Chlorides

Various substituted and unsubstituted N -heteroaryl chlorides have been converted into their corresponding organozinc species using zinc dust in the presence of zinc pivalate and 10% CoCl 2in benzonitrile at 25 °C. The resulting heteroarylzinc

CHEMICAL PROCESS

The present invention provides, inter alia, a process for producing a compound of formula (I)) wherein the substituents are as defined in claim 1. The present invention further provides intermediate compounds utilised in said process, and methods for producing said intermediate compounds.

Double-fold C-H oxygenation of arenes using PyrDipSi: A general and efficient traceless/modifiable silicon-tethered directing group

The efficient Pd-catalyzed double-fold C-H oxygenation of arenes into resorcinols using the newly developed 2-pyrimidyldiisopropylsilyl (PyrDipSi) directing group is described. Its use allows for the sequential introduction of OAc and OPiv groups in a one-pot manner to produce orthogonally protected resorcinol derivatives. The PyrDipSi group is superior to the previously developed 2-pyridyldiisopropylsilyl (PyDipSi) group, as it is efficient for monooxygenation of ortho-substituted arenes. Notably, the PyrDipSi group can be easily installed into arene molecules and can be easily removed or modified after the oxygenation reaction.

FLUORESCENT SOLVATOCHROMIC PIGMENT

The present invention presents a novel fluorescent solvatochromic dye that (1) has an ionic terminal that makes it easier to use n a hydrophilic surface or in polar solvents, (2) can be efficiently excited by commonly used Argon lasers (488 nm), (3) shift

Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols

The present invention relates to a process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols having the structural formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R is benzyl, R5-benzyl, allyl, —C(O)R6, —C(O)OR8 or —CH(R7)2; R1 is optionally substituted aryl or optionally substituted heteroaryl; and R5, R6, R7 and R8 are as defined in the specification; comprising a) reacting an amine of formula II [in-line-formulae]R—NH2??II [/in-line-formulae] with 2,5-dimethoxytetrahydrofuran or HC(O)(CH2)2C(O)H, and C(O)(CH2C(O)OR4)2, wherein R4 is H or alkyl, to obtain a compound of formula III b) reacting a compound of formula III with I-R1, alkyl lithium, and optionally a lithium salt, to obtain a compound of formula I; and c) optionally converting a compound of formula I wherein R is benzyl, R5-benzyl, allyl, —C(O)R6 or —C(O)OR6 to a compound of formula I wherein R is —CH(R7)2. Intermediates in the process are also claimed.

Improved synthesis of 2,2′-bipyrimidine

A high-yield synthesis was developed for the preparation of 2,2′-bipyrimidine (1) using the Ullmann coupling of 2-iodopyrimidine. The new procedure was also used for the preparation of 4,4′,6,6′-tetramethyl-2,2′-bipyrimidine (2) and 5,5′-dibromo-2,2′-bipyrimidine (3).

Isatogens: Further Studies of Crystal Structure, Electron Density, and 13C and 15N NMR Spectra

The structures of 2-(pyrimidin-2-yl) (1c), 2-methoxycarbonylisatogen (1d), and 2-(1-ethyl-benzimidazol-2-yl)isatogen (1e) have been determined by X-ray crystallography.The dihedral angle between the isatogen ring and the plane of the 2-substituent varies