314764-25-5

Upstream product

• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 68029-57-2 2-cyano-3-(4-methoxyphenyl)thioacrylamide 
• 109012-86-4 3-(4-methoxyphenyl)-2-cyano-5-phenyl-5-oxo-pentano-nitrile 
• 78564-17-7 3-cyano-4-(4-methoxyphenyl)-6-phenylpyridine-2(1H)-thione 
• 96-34-4 methyl chloroacetate 

Relevant academic research and scientific papers

Unexpected formation of 4-aryl-3-cyano-6-phenylpyridine-2(1H)-thiones from the reaction of arylmethylenecyanothioacetamides with benzoyl-1,1,1- trifluoroacetone

4-Aryl-3-cyano-6-phenylpyridine-2(1H)-thiones, used in the synthesis of substituted 2-alkylthiopyridines, thieno[2,3-b]pyridines, and 1,4-di(pyridin-2-ylthio)butane, have been synthesized by the condensation of arylmethylenecyanothioacetamides with benzoyl-1,1,1-trifluoroacetone. The reaction path includes the formation of the Michael adduct which undergoes loss of the acyl group. The structure of 3-cyano-2-methylthio-4-(1-naphthyl)-6- phenylpyridine has been studied by X-ray crystallography. 2005 Springer Science+Business Media, Inc.