314775-78-5

Basic information

• Product Name: 2-acetyl-3-(3-chlorophenyl)-acrylic acid (2-cyanoethyl) ester
• Synonyms: 2-acetyl-3-(3-chlorophenyl)-acrylic acid (2-cyanoethyl) ester
• CAS NO: 314775-78-5
• Molecular Weight: 277.707
• Mol File: 314775-78-5.mol

Chemical Properties

• CAS DataBase Reference: 2-acetyl-3-(3-chlorophenyl)-acrylic acid (2-cyanoethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-3-(3-chlorophenyl)-acrylic acid (2-cyanoethyl) ester(314775-78-5)
• EPA Substance Registry System: 2-acetyl-3-(3-chlorophenyl)-acrylic acid (2-cyanoethyl) ester(314775-78-5)

Safety Data

• Hazardous Substances Data: 314775-78-5(Hazardous Substances Data)

Upstream product

• 65193-87-5 2-cyanoethylacetoacetate 
• 587-04-2 m-Chlorobenzaldehyde 
• 2039-85-2 3-Chlorostyrene 

Downstream Products

• 314775-79-6 5-(2-cyanoethyl) 3-(3,3-diphenylpropane-1-yl) 2-(2-benzyloxyethoxymethyl)-4-(3-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-3,5-dicarboxylate 
• 404569-99-9 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-cyanoethyl) ester 5-(3-(4-(5H-dibenzo[a,d] cyclohepten-5-ylidene) piperidine-1-yl) propan-1-yl) ester 

Relevant articles and documents

Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

An efficient asymmetric synthesis of 1,4-dihydropyridine derivatives is described. The key step is the stereoselective Michael addition using t-butyl ester of l-valine as a chiral auxiliary to achieve good ee (>95% for all the tested experiments) and moderate yield. With this method, (+)-4-(3-chlorophenyl) -6-dimethoxymethyl-2-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid cinnamyl ester was obtained and was characterized as a promising N-type calcium channel blocker with improved selectivity over L-type compared to its (-)- and racemic isomers.

DIHYDROPYRIDINE DERIVATIVE

Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.