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10,11-Dimethoxy-19β-methyl-16,17-didehydro-18-oxayohimban-16-carboxylic acid methyl ester is a yohimbine type alkaloid, which is a naturally occurring organic compound found in the plant Rauwolfia vomitora. This specific alkaloid can be purified through a process of recrystallization from methanol, resulting in the formation of colorless leaflets of the hemihydrate. It forms crystalline salts, such as the hydrochloride with a melting point of 280-2°C and the tartrate with a melting point of 215-6°C (decomposition). The alkaloid exhibits dextrorotatory optical activity with a specific rotation of [α]D +32.5° (c 1.0, CHCl3). Its molecular structure is characterized by the presence of 10-methoxyraunitidine.

3148-42-3

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3148-42-3 Usage

Uses

1. Used in Pharmaceutical Industry:
10,11-Dimethoxy-19β-methyl-16,17-didehydro-18-oxayohimban-16-carboxylic acid methyl ester is used as a pharmaceutical compound for its potential therapeutic applications. The alkaloid's unique structure and properties make it a candidate for the development of new drugs, particularly in the treatment of various medical conditions.
2. Used in Chemical Research:
This yohimbine type alkaloid is also utilized in chemical research for studying the structure-activity relationships of similar compounds and for understanding the mechanisms of action of natural products with potential medicinal value.
3. Used in Drug Synthesis:
10,11-Dimethoxy-19β-methyl-16,17-didehydro-18-oxayohimban-16-carboxylic acid methyl ester can be employed as a key intermediate in the synthesis of other bioactive compounds, contributing to the development of novel drugs with improved pharmacological properties.
4. Used in Analytical Chemistry:
The alkaloid can be used as a reference compound in analytical chemistry for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or gas chromatography (GC), for the identification and quantification of related compounds in complex mixtures.
5. Used in Toxicological Studies:
10,11-Dimethoxy-19β-methyl-16,17-didehydro-18-oxayohimban-16-carboxylic acid methyl ester may be utilized in toxicological studies to evaluate the safety and potential side effects of 10,11-Dimethoxy-19β-methyl-16,17-didehydro-18-oxayohimban-16-carboxylic acid methyl ester and its derivatives, ensuring the development of safe and effective drugs.

References

Goutarel, Gut, Parello., Compt. rend., 253, 2589 (1961) Finch et al., Tetrahedron, 22, 1327 (1966)

Check Digit Verification of cas no

The CAS Registry Mumber 3148-42-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,4 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3148-42:
(6*3)+(5*1)+(4*4)+(3*8)+(2*4)+(1*2)=73
73 % 10 = 3
So 3148-42-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H28N2O5/c1-12-16-10-25-6-5-13-15-8-20(27-2)21(28-3)9-18(15)24-22(13)19(25)7-14(16)17(11-30-12)23(26)29-4/h8-9,11-12,14,16,19,24H,5-7,10H2,1-4H3/t12-,14+,16-,19+/m1/s1

3148-42-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 10,11-dimethoxy-19β-methyl-18-oxa-yohimb-16-ene-16-carboxylic acid methyl ester

1.2 Other means of identification

Product number -
Other names Rauvanin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3148-42-3 SDS

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