31488-84-3Relevant academic research and scientific papers
TNF -Alpha Modulating Benzimidazoles
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Paragraph 0491, (2015/06/10)
A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Br?nsted acid catalyzed monoalkylation of anilines with trichloroacetimidates
Wallach, Daniel R.,Stege, Patrick C.,Shah, Jigisha P.,Chisholm, John D.
, p. 1993 - 2000 (2015/02/19)
Trichloroacetimidates are useful alkylating agents for aromatic amines, requiring only a catalytic amount of a Br?nsted acid to facilitate the reaction. Monoalkylation predominates under these conditions. Electron-poor anilines provide superior yields, with electron-rich anilines sometimes showing competitive Friedel-Crafts alkylation. A single flask protocol with formation of the imidate in situ is demonstrated, providing a convenient method for the direct substitution of alcohols with anilines. Reaction with a chiral imidate favors a mechanism that proceeds through a carbocation intermediate.
