31489-18-6Relevant academic research and scientific papers
Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: Application to the synthesis of vernakalant
Garad, Dnyaneshwar N.,Tanpure, Subhash D.,Mhaske, Santosh B.
, p. 1008 - 1016 (2015/08/18)
Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.
Process for the production of maleimides
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, (2008/06/13)
There is described a process for the production of maleimides, particularly N-substituted maleimides or N,N'-bis-maleimides, by isomerization of the corresponding isoimides in the presence of specific catalysts, such as mixtures of phenol and triethylamine. Maleimides of high purity and in good to very good yields under mild conditions and with the use of small amounts of catalyst are obtained by the process according to the invention.
