315-44-6

Usage

Uses

Used in Organic Synthesis:
Ethanone, 1-(2,4-dihydroxyphenyl)-2,2,2-trifluoro(9CI) is used as a building block in organic synthesis for the creation of various biologically active compounds. Its unique structure allows for the development of new molecules with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Ethanone, 1-(2,4-dihydroxyphenyl)-2,2,2-trifluoro(9CI) serves as a key intermediate in the synthesis of drugs. Its properties make it a valuable component in the development of new medications with improved efficacy and reduced side effects.
Used in Material Development:
Ethanone, 1-(2,4-dihydroxyphenyl)-2,2,2-trifluoro(9CI) has potential applications in the development of new materials. Its unique chemical structure can contribute to the creation of innovative materials with enhanced properties for various applications.
Used as a Reagent in Chemical Analysis:
In the field of chemical analysis, Ethanone, 1-(2,4-dihydroxyphenyl)-2,2,2-trifluoro(9CI) can be employed as a reagent. Its distinctive characteristics make it suitable for use in analytical processes, potentially improving the accuracy and efficiency of chemical tests.

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 108-46-3 recorcinol 
• 353-85-5 trifluoroacetonitrile 

Downstream Products

• 65239-82-9 1-[2,4-Dihydroxy-3-(4-methyl-cyclohexyl)-phenyl]-2,2,2-trifluoro-ethanone 
• 65239-70-5 1-(2,4-Dihydroxy-3-isopropyl-phenyl)-2,2,2-trifluoro-ethanone 
• 65239-74-9 1-(5-tert-Butyl-2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone 
• 724466-51-7 1-(2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone oxime 
• 843646-57-1 (2,4-dichloro-phenyl)-(6-hydroxy-3-trifluoromethyl-benzofuran-2-yl)-methanone 
• 65240-38-2 1-{5-[2,4-Dihydroxy-3-isopropyl-5-(2,2,2-trifluoro-acetyl)-benzyl]-2,4-dihydroxy-3-isopropyl-phenyl}-2,2,2-trifluoro-ethanone 
• 709028-30-8 {3-Chloro-4-[3-(3-hydroxy-2-propyl-4-{2,2,2-trifluoro-1-[(Z)-hydroxyimino]-ethyl}-phenoxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 
• 709028-29-5 (3-Chloro-4-{3-[3-hydroxy-2-propyl-4-(2,2,2-trifluoro-acetyl)-phenoxy]-propylsulfanyl}-phenyl)-acetic acid methyl ester 
• 194608-89-4 {3-chloro-4-[3-(7-propyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 
• 709028-25-1 1-(3-allyl-2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone 
• 65239-69-2 2,4-dihydroxy-3-propyl-1',1',1'-trifluoroacetophenone 
• 194608-88-3 7-dipropyl-6-hydroxy-3-trifluoromethyl-1,2-benzisoxazole 
• 65240-20-2 1-(3-Cyclopentyl-2,4-dihydroxy-phenyl)-2,2,2-trifluoro-ethanone 
• 65240-14-4 1-[2,4-Dihydroxy-3-(toluene-4-sulfonyl)-phenyl]-2,2,2-trifluoro-ethanone 

Relevant academic research and scientific papers

Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases

Phloroglucinol reductases (PGRs) are involved in anaerobic degradation in bacteria, in which they catalyze the dearomatization of phloroglucinol into dihydrophloroglucinol. We identified three PGRs, from different bacterial species, that are members of the family of NAD(P)H-dependent short-chain dehydrogenases/reductases (SDRs). In addition to catalyzing the reduction of the physiological substrate, the three enzymes exhibit activity towards 2,4,6-trihydroxybenzaldehyde, 2,4,6-trihydroxyacetophenone, and methyl 2,4,6-trihydroxybenzoate. Structural elucidation of PGRcl and comparison to known SDRs revealed a high degree of conservation. Several amino acid positions were identified as being conserved within the PGR subfamily and might be involved in substrate differentiation. The results enable the enzymatic dearomatization of monoaromatic phenol derivatives and provide insight into the functional diversity that may be found in families of enzymes displaying a high degree of structural homology.

Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities

The synthesis and structure-activity relationship studies of novel indole derivatives as peroxisome proliferator-activated receptor (PPAR) agonists are reported. Indole, a druglike scaffold, was studied as a core skeleton for the acidic head part of PPAR