315-72-0

Basic information

• Product Name: OPIPRAMOL
• Synonyms: OPIPRAMOL;4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol;N-[3-[4-(2-hydroxyethyl)piperazino]propyl]iminostilbene;1-Piperazineethanol, 4-3-(5H-dibenzb,fazepin-5-yl)propyl-;4-(3-(DIBENZ(B,F)AZEPIN-5-YL)PROPYL)-1-PIPERAZINEETHANOL;G-33040;GR-33040;Nisidana
• CAS NO: 315-72-0
• Molecular Formula: C23H29N3O
• Molecular Weight: 363.5
• EINECS: 206-254-0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 315-72-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 100-1010C
• Boiling Point: 494.88°C (rough estimate)
• Flash Point: 290.5 °C
• Appearance: /
• Density: 1.0920 (rough estimate)
• Refractive Index: 1.6500 (estimate)
• Storage Temp.: -20°C Freezer
• PKA: pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain)
• BRN: 627076
• CAS DataBase Reference: OPIPRAMOL(CAS DataBase Reference)
• NIST Chemistry Reference: OPIPRAMOL(315-72-0)
• EPA Substance Registry System: OPIPRAMOL(315-72-0)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 1
• RTECS: TL8750000
• Hazardous Substances Data: 315-72-0(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline Solid

Originator

Insidon,Geigy,W. Germany,1962

Uses

Antidepressant; antipsychotic

Manufacturing Process

A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours. After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C.

Therapeutic Function

Antidepressant, Antipsychotic

InChI:InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2

Upstream product

• 98-54-4 para-tert-butylphenol 
• 96-76-4 2,4-di-tert-Butylphenol 

Downstream Products

• 107088-83-5 8-(3-<4-(2-hydroxyethyl)piperazinyl>propyl)-8H-dibenz<1>oxa<2,5>diazolo<3,4-d>azepine 1-oxide 

Relevant articles and documents

Preparation method of phosphite antioxidant 168

The invention discloses a preparation method of a phosphite antioxidant 168 and belongs to the technical field of antioxidant preparation. The preparation method is as follows: adding excessive 2,4-di-tert-butylphenol and a catalyst into a reaction kettle, adding phosphorus trichloride, and carrying out a synthetic reaction to generate tri(2,4-di-tert-butyl)phosphite; then, adding an anti-hydrolytic agent, then, carrying out filtration, and evaporating the excessive 2,4-di-tert-butylphenol in filtrate to obtain a crude product of tri(2,4-di-tert-butyl)phosphite; and then, crystallizing the crude product, and carrying out centrifuging, washing and drying to obtain a final finished product. By using the preparation method of the phosphite antioxidant 168, the consumption of raw materials isreduced, a reaction solvent is reduced, the reaction time is shortened, and the generation amount of byproducts is low; and a phosphite antioxidant 168 product prepared by using the preparation methodhas the characteristics of high purity (larger than or equal to 99%, low acid value (smaller than or equal to 0.3 mgKOH/g) and good hydrolysis resistance (PH is larger than or equal to 7).

SOLID ALKYLARYL PHOSPHITE COMPOSITIONS AND METHODS FOR MANUFACTURING SAME

The invention is directed to various alkylaryl phosphite compositions that ideally are suitable for use as secondary antioxidants in polymers. In one aspect, the phosphite composition comprises a tris(dialkylaryl)phosphite in an amount from 20 to 93 weight percent; and at least one of: a bis(dialkylaryl)monoalkylaryl phosphite; a bis(monoalkylaryl)dialkylaryl phosphite; and a tris(monoalkylaryl) phosphite. The inventive phosphite composition is a solid at ambient conditions. The invention also relates to alkylate compositions and processes for forming such alkylate compositions and such phosphite compositions.

Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith

Hindered amines substituted on the N-atom with an hydroxy-substituted alkoxy moiety are particularly effective in stabilizing organic polymer compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of the OH group on the compounds adds important properties not otherwise attainable.