31502-94-0Relevant academic research and scientific papers
A convenient, highly stereoselective, metal-free synthesis of chiral amines
Guizzetti, Stefania,Benaglia, Maurizio,Biaggi, Cinzia,Celentano, Giuseppe
supporting information; experimental part, p. 134 - 136 (2010/07/16)
A low cost, efficient, metal-free highly stereoselective reduction of ketimines to chiral amines was developed. Different imines bearing a very cheap and removable chiral auxiliary were reduced simply by trichlorosilane in the presence of N,N-dimethylformamide, often in quantitative yield and complete control of the absolute stereochemistry, to afford highly enantiomerically enriched amines. Georg Thieme Verlag Stuttgart.
Highly stereoselective metal-free catalytic reduction of Lmines: An easy entry to enantiomerically pure amines and natural And Unnatural α-amino esters
Gulzzettl, Stefania,Benagila, Maurizio,Rossi, Sergio
supporting information; experimental part, p. 2928 - 2931 (2009/12/05)
A highly efficient catalytic stereoselective ketlmlne reduction is described. The combination of an Inexpensive chiral organocatalyst, easily prepared In a single step, and of a very cheap removable chiral auxiliary allowed us to obtain enantlomerlcally pure amino compounds. The methodology allowed synthesis of chiral secondary and primary amines and natural and unnatural amino esters In high yields often with total control of the absolute stereochemistry.
