315178-33-7

Upstream product

• 5780-00-7 2-methoxy-4,5-methylenedioxybenzaldehyde 
• 73968-62-4 (5S)-5-[(trityloxy)methyl]tetrahydro-2-furanone 

Downstream Products

• 315178-34-8 (2S,4S)-2-[(1S)-1-methoxymethoxy-1-(2-methoxy-4,5-methylenedioxyphenyl)methyl]-5-trityloxy-4-pentanolide 
• 315178-35-9 (2S,4R,5S)-5-methoxymethoxy-5-(2-methoxy-4,5-methylenedioxyphenyl)-4-pivaloyloxymethyl-1-trityloxy-2-pentanol 

Relevant academic research and scientific papers

Improved stereoselective synthesis of optically active methylene lactone, key intermediate for the synthesis of 1,2-oxidized furofuran lignan, by direct alpha-methylenation to butanolide.

(3R)-3-[(1R)-1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl) methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L-glutamic acid by applying direct methylenation to butanolide.