315178-41-7

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 315178-40-6 (2S,4S)-2-[(1R)-1-hydroxy-1-(2-methoxy-4,5-methylenedioxyphenyl)methyl]-5-trityloxy-4-pentanolide 
• 5780-00-7 2-methoxy-4,5-methylenedioxybenzaldehyde 
• 73968-62-4 (5S)-5-[(trityloxy)methyl]tetrahydro-2-furanone 

Downstream Products

• 315178-42-8 2,2-Dimethyl-propionic acid (2R,4S)-4-hydroxy-2-[(R)-(6-methoxy-benzo[1,3]dioxol-5-yl)-methoxymethoxy-methyl]-5-trityloxy-pentyl ester 

Relevant academic research and scientific papers

Improved stereoselective synthesis of optically active methylene lactone, key intermediate for the synthesis of 1,2-oxidized furofuran lignan, by direct alpha-methylenation to butanolide.

(3R)-3-[(1R)-1-(tert-Butyldimethylsilyl)oxy-1-(2-methoxy-4,5-methylenedioxyphenyl) methyl]-2-methylene-4-butanolide, which is a key intermediate for the synthesis of 1,2-oxidized furofuran lignan, was stereoselectively synthesized from L-glutamic acid by applying direct methylenation to butanolide.