315230-87-6Relevant academic research and scientific papers
Fe3O4@NCs/BF0.2: A magnetic bio-based nanocatalyst for the synthesis of 2,3-dihydro-1H-perimidines
Mirjalili, Bi Bi Fatemeh,Imani, Mahnaz
, p. 1542 - 1549 (2019/05/15)
Nanocellulose (NC) materials have some unique properties, which make them attractive as organic or inorganic supports for catalytic applications. Nanocatalysts with diameters of less than 100 nm are difficult to separate from the reaction mixture, therefo
Nano-γ-Al2O3/SbCl5: An efficient catalyst for the synthesis of 2,3-dihydroperimidines
Bamoniri, Abdolhamid,Fatemeh Mirjalili, Bi Bi,Saleh, Sepideh
, p. 6178 - 6182 (2018/02/14)
Nano-γ-Al2O3/SbCl5 as a new Lewis acid nano catalyst was synthesized and characterized by FTIR, XRD, FESEM, TEM, EDS, BET and TGA techniques. Nano-γ-Al2O3/SbCl5 has been employed for synthe
A class of 2, 3 - dihydronaphth block pyrimidine analogs, its synthetic method, pharmaceutical composition and use thereof
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, (2017/07/22)
The invention belongs to the technical field of medicines and relates to a 2,3-dihydronaphthalene-embedded m-diazabenzene analogue represented as the following general formula I and a preparation method thereof. The 2,3-dihydronaphthalene-embedded m-diazabenzene analogue has a function of inhibiting biological activities of different subtypes of a protein-tyrosine-phosphatase family (PTPases), can be used as a tool compound for researching a biological function correlation of the subtypes of the protein-tyrosine-phosphatase family (PTPases) in a cell signal transduction process, and provides a new approach for preventing and treating cancer, metabolic and immunological diseases, angiocardiopathy and neurological diseases.
1H-2,3-Dihydroperimidine derivatives: A new class of potent protein Tyrosine Phosphatase 1B inhibitors
Wang, Wen-Long,Yang, Dong-Lin,Gao, Li-Xin,Tang, Chun-Lan,Ma, Wei-Ping,Ye, Hui-Hua,Zhang, Si-Qi,Zhao, Ya-Nan,Xu, Hao-Jie,Hu, Zhao,Chen, Xia,Fan, Wen-Hua,Chen, Hai-Jun,Li, Jing-Ya,Nan, Fa-Jun,Li, Jia,Feng, Bainian
, p. 102 - 121 (2014/02/14)
A series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivity (3.48-fold and 2.10-fold respectively) over T-cell protein tyrosine phosphatases (TCPTP). These results have provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
