3153-01-3

Basic information

• Product Name: 2,3,5,6-TETRAFLUORO-4-METHOXYBENZOIC ACID
• Synonyms: 2,3,5,6-TETRAFLUORO-4-METHOXYBENZOIC ACID
• CAS NO: 3153-01-3
• Molecular Formula: C₈H₄F₄O₃
• Molecular Weight: 224.1091728
• Mol File: 3153-01-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3,5,6-TETRAFLUORO-4-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-TETRAFLUORO-4-METHOXYBENZOIC ACID(3153-01-3)
• EPA Substance Registry System: 2,3,5,6-TETRAFLUORO-4-METHOXYBENZOIC ACID(3153-01-3)

Safety Data

• Hazardous Substances Data: 3153-01-3(Hazardous Substances Data)

Usage

General Description

2,3,5,6-Tetrafluoro-4-methoxybenzoic acid is a chemical compound with the molecular formula C8H5F4O3. It is a white crystalline solid with a melting point of 190-192°C. This chemical is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other fluorinated compounds. 2,3,5,6-Tetrafluoro-4-methoxybenzoic acid is a highly fluorinated compound, making it useful in applications where chemical stability and resistance to degradation are important. Additionally, it can be used as a building block in organic chemistry for the synthesis of various complex molecules.

Upstream product

• 602-94-8 Pentafluorobenzoic acid 
• 13557-43-2 1,2-bis(pentafluorophenyl)acetylene 
• 14865-77-1 p-CH₃OC₆F₄C₂C₆F₄OCH₃ 
• 131684-02-1 2-(2,3,4,5-tetrafluoro-6-methoxyphenyl)-4,4-dimethyl-2-oxazoline 

Downstream Products

• 17490-79-8 methyl 2,3,5,6-tetrafluoro-4-methoxy benzoate 

Relevant articles and documents

Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship

A series of 5-amino- and 5-hydroxyquinolone antibacterials substituted at C7 with a select group of common piperazinyl and 3-aminopyrrolidinyl side chains was prepared. These 5-substituted derivatives were compared to the analogous 5-hydrogen compounds for antiinfective activity by using DNA gyrase inhibition, minimum inhibitory concentrations against a variety of bacteria, and in vivo efficacy in the mouse infection model. The influence on the structure-activity relationships of varied substituents at C8 (H, F, Cl) and N1 (ethyl, cyclopropyl, difluorophenyl) was also studied. The results showed that several of the structure-activity conclusions regarding side-chain bulk at C7, the effect of halogen at C8, and the effect of the C5-amino group were greatly influenced by the choice of the N1-substituent. Several outstanding broad spectrum quinolones were identified in this work. In particular, the spectrum and potency of the 7-piperazinyl quinolones could be greatly enhanced by the judicious choice of C5-, C8-, and N1-substitutents.

Halogenated esters

Compounds of formula (I), useful as insecticides and knockdown agents: STR1 where Y is C1-6 alkoxy, Z is halo or C1-6 alkoxy; R is --(CH2)p --(O)m --R3 where m and p may be 0 or 1; R3