31535-27-0

Usage

Uses

Used in Chemical and Biochemical Research:
Cytidine, 5-fluoro-, 5'-(dihydrogen phosphate) (8CI) is utilized as a precursor in the synthesis of various nucleotide analogs and nucleic acid derivatives. Its role in this capacity aids researchers in developing new compounds and understanding the fundamental chemistry and biology of nucleic acids.
Used in Pharmaceutical Development:
Cytidine, 5-fluoro-, 5'-(dihydrogen phosphate) (8CI) is studied for its potential pharmacological applications, particularly in the areas of antiviral and anticancer treatments. The presence of the 5-fluoro group and the dihydrogen phosphate group may confer specific biological activities that can be harnessed to combat viral infections or cancer cells.
Used in Studying Fluorine Substitutions:
The structural modifications of Cytidine, 5-fluoro-, 5'-(dihydrogen phosphate) (8CI), specifically the fluorine substitution, make it a useful tool for investigating the effects of such substitutions on nucleoside metabolism and interactions within biological systems. This can lead to insights that improve drug design and the understanding of nucleoside-based therapies.

Upstream product

• 4590-33-4 5-fluorocytidine hydrochloride 

Relevant academic research and scientific papers

Synthesis and Antitumor and Antiviral Activities of a Series of 1-β-D-Ribofuranosyl-5-halocytosine (5-Halocytidine) Cyclic 3',5'-Monophosphates

A series of 1-β-ribofuranosyl-5-halocytosine cyclic 3',5'-monophosphates (1-4) has been prepared.Direct halogenation of cytidine 3',5'-monophosphate (cCMP) yielded the Cl,Br, and I compounds while 5-F-cCMP (1) was obtained on cyclization of the 5'-monophosphate.On in vitro testing of 1-4 against L1210 and P388 leukemias, only 1 showed significant low-level activity (ID50=3.1*10-4 mmol/L).Derivatives 2-4 were inactive at 10-1 mmol/L and also proved to have low viral ratings against a series of RNA and DNA virus strains in vitro.By contrast the 5-F-cCMP showed moderate activity against VV, HSV-1, and HSV-2 strains (VR=0.6-0.9).Both 5-fluorocytidine and 5-fluorocytidine-5'-monophosphate had marked antiviral activity (VR=1.0-2.1) with the above viruses as well as with parainfluenza virus type 3.The nucleoside and nucleotide also were more active than 5-F-cCMP against L1210 and P388 cells.However, comparison of the cytoxicities and antiviral ED50 values of 5-F-cCMP, 5-fluorocytidine 5'-monophosphate, and 5-fluorocytidine suggests a potential therapeutic advantage for 5-F-cCMP.Possible rationales for these activities are discussed in terms of 5-F-cCMP and the corresponding 5'-monophosphate as potential prodrugs and as sources, following enzymatic deamination, of cytotoxic 5-fluorouridine or its 5'-monophosphate