31537-71-0

Basic information

• Product Name: 2-acetyl-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
• Synonyms: 2-acetyl-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline;1-(3,4-Dimethoxybenzyl)-2-acetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;1-[1-(3,4-Dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline-2(1H)-yl]ethanone;2-Acetyl-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;rac N-Acetyl Norlaudanosine;1-[1-[(3,4-DiMethoxyphenyl)Methyl]-3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl]ethanone
• CAS NO: 31537-71-0
• Molecular Formula: C₂₂H₂₇NO₅
• Molecular Weight: 385.45348
• EINECS: 250-686-2
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 31537-71-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 548.5°Cat760mmHg
• Flash Point: 285.5°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 4.42E-12mmHg at 25°C
• Refractive Index: 1.556
• PKA: -1.05±0.40(Predicted)
• CAS DataBase Reference: 2-acetyl-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline(31537-71-0)
• EPA Substance Registry System: 2-acetyl-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline(31537-71-0)

Safety Data

• Hazardous Substances Data: 31537-71-0(Hazardous Substances Data)

Usage

Uses

rac N-Acetyl Norlaudanosine is used in forensic analysis.

InChI:InChI=1/C22H27NO5/c1-14(24)23-9-8-16-12-21(27-4)22(28-5)13-17(16)18(23)10-15-6-7-19(25-2)20(11-15)26-3/h6-7,11-13,18H,8-10H2,1-5H3

Upstream product

• 72527-19-6 2-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]thioacetamide 
• 139-76-4 N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 340829-03-0 N-(2-{2-[2-(3,4-dimethoxy-phenyl)-vinyl]-4,5-dimethoxy-phenyl}-ethyl)-acetamide 
• 269407-38-7 10b-(3,4-dimethoxybenzyl)-8,9-dimethoxy-6,10b-dihydro-5H-thiazolo[2,3-a]isoquinolin-3-one 
• 108-24-7 acetic anhydride 
• 13074-31-2 Tetrahydropapaverine 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 

Relevant articles and documents

Photochemically induced cyclization of N-[2-(o-styryl)phenylethyl]acetamides and 5-styryl-1-methyl-1,2,3,4-tetrahydroisoquinolines: New total syntheses of 1-methyl-1,2,3,4-tetrahydronaphtho[2,1-f]isoquinolines

Two new total syntheses of 1-methyl-1,2,3,4-dihydronaphtho[1,2-f]isoquinolines are based on photochemically induced cyclization of N-{2-[(E)-2-phenyl-1-etheynyl]phenylethyl]}acetamides or 1-methyl-5-[(E)-2-phenyl-1-ethenyl]-1,2,3,4-tetrahydroisoquinolines.

Illicit Heroin Manufacturing Byproducts: Copillary Gas Chromatographic Determination and Structural Elucidation of Narcotine- and Norlaudanosine-Related Compounds

Capillary gas chromatographic methodology is described for detection of trace quantities of narcotine- and norlaudanosine-related manufacturing impurities in illicit heroin.N-Acetylnornarcotine (2), N-acetylanhydronornarceine (3a,b), 1-acetoxy-N-acetylanhydro-1,9-dihydronornarceine (4a,b),and (E)-3-acrylic acid(5) result from the reaction of narcotine (1) with acetic anhydride.The treatment of norlaudanosine (11a) with acetic anhydride yields N-acetylnorlaudanosine (9).After isolation from thebulk heroin matrix, these impurities, along with morphine, codeine, and thebaine byproducts, are detected by using both fused silica and glass capillary columns in the split mode with flame ionization detection.The syntheses and spectral characterization of these impurities are described.