31556-28-2 Usage
Uses
Used in Biochemical and Molecular Biology Research:
4-thiouridine triphosphate is used as a substrate for RNA polymerase to study RNA synthesis and structure. Its incorporation into RNA molecules during transcription enables researchers to investigate the effects of sulfur substitution on RNA stability and interactions.
Used in RNA Structure and Function Studies:
4-thiouridine triphosphate is used as a research tool for examining the structure and function of RNA, providing insights into the molecular mechanisms of RNA biology.
Used in Photoaffinity Labeling:
In the field of biochemical assays, 4-thiouridine triphosphate is used as a component in photoaffinity labeling techniques to study RNA-protein interactions and RNA modification processes, aiding in the elucidation of complex molecular interactions within biological systems.
Overall, 4-thiouridine triphosphate is a significant asset in molecular biology research, contributing to a deeper understanding of RNA biology through its diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 31556-28-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,5,5 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 31556-28:
(7*3)+(6*1)+(5*5)+(4*5)+(3*6)+(2*2)+(1*8)=102
102 % 10 = 2
So 31556-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H15N2O14P3S/c12-6-4(3-22-27(18,19)25-28(20,21)24-26(15,16)17)23-8(7(6)13)11-2-1-5(29)10-9(11)14/h1-2,4,6-8,12-13H,3H2,(H,18,19)(H,20,21)(H,10,14,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
31556-28-2Relevant academic research and scientific papers
BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN
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, (2010/03/31)
The present application describes a base-modified RNA and the use thereof for increasing the expression of a protein and for the preparation of a pharmaceutical composition, especially a vaccine, for the treatment of tumours and cancer diseases, heart and circulatory diseases, infectious diseases, autoimmune diseases or monogenetic diseases, for example in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the base-modified RNA, and an in vivo method.
4-Substituted uridine 5′-triphosphates as agonists of the P2y2 purinergic receptor
Shaver, Sammy R.,Pendergast, William,Siddiqi, Suhaib M.,Yerxa, Benjamin R.,Croom, Dallas K.,Dougherty, Robert W.,James, Michael K.,Neil Jones,Rideout, Janet L.
, p. 1099 - 1102 (2007/10/03)
Undine 5′-O-triphosphate (UTP) is a potent agonist of the purinergic receptor designated P2Y2. UTP is rapidly metabolized in human tissue. To find a compound with similar activity that may be more slowly metabolized, a series of 4-substituted uridine 5′-triphosphates were prepared and evaluated in a P2Y2 receptor second messenger assay. Copyright
