31557-67-2Relevant academic research and scientific papers
Ru(II)-Catalyzed Difunctional Pyridyloxy-Directed Regio-and Stereospecific Addition of Carboxylic Acids to Internal Alkynes
Wang, Qin,Shi, Yan,Huang, Xiaoli,Wang, Yongzhuang,Jiao, Jiao,Tang, Yuhai,Li, Jing,Xu, Silong,Li, Yang
, p. 379 - 384 (2022/01/11)
A highly efficient Ru(II)-catalyzed regio- and stereospecific hydro-oxycarbonylation of unsymmetrical internal alkynes bearing a difunctional 2-pyridyloxy directing group with carboxylic acids has been developed, which provides allylic (Z)-enol esters in good to excellent yields with a broad substrate scope under mild conditions. The difunctional directing group can be diversely derivatized, particularly undergoing allylic substitution with various nucleophiles to afford β-functionalized (Z)-enol esters without directing groups.
