31557-89-8

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 105-56-6 ethyl 2-cyanoacetate 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1266388-01-5 2-cyano-3-(dimethylamino)-N-(4-phenylthiazol-2-yl)acrylamide 
• 1266388-19-5 4-amino-N-(4-phenyl-1,3-thiazol-2-yl)pyrimido[1,2-a]benzimidazole-3-carboxamide 
• 1266388-15-1 2-cyano-N-(4-phenylthiazol-2-yl)-3-(4-phenylthiazol-2-ylamino)-acrylamide 
• 1266388-16-2 5-oxo-3-phenyl-N-(4-phenylthiazol-2-yl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide 

Relevant academic research and scientific papers

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Behavior of 2-cyano-3-(dimethylamino)-7V-(4-phenylthiazol-2-yl)-acrylamide towards some nitrogen nucleophiles

The versatile, hitherto unreported 2-cyano-3-(dimethylamino)-VV-(4- phenylthiazol-2-yl)-acrylamide 2 was synthesized and allowed to react with hydroxylamine, hydrazine and guanidine to afford regioselectively the isoxazole 4, pyrazole 6 and pyrimidine 8 d

Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists

4-(4-Methoxyphenyl)-2-aminothiazole and 3-(4-methoxyphenyl)-5- aminothiadiazole derivatives have been synthesized and evaluated as selective antagonists for human adenosine A3 receptors. A methoxy group in the 4-position of the phenyl ring and

Versatile 2-aminothiazoles, building blocks for highly functionalised heterocycles

The reactions of quantitatively available 4-phenyl- and 4-(4-antipyrinyl)-2-aminothiazole ["4-antipyrinyl-" is used as a short-term for " 4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1-H-pyrazol-4yl)-"] with chloroacetyl chloride, acetic anhydride, ethyl cy