315669-99-9

Basic information

• Product Name: N-(3-Acetylphenyl)-3-methylbenzamide
• Synonyms: N-(3-Acetylphenyl)-3-methylbenzamide;ARONIS021211;BIM-0023726.P001;CBMicro_023739;CDS1_004155;DivK1c_005195;MixCom6_000763;N-(3-ethanoylphenyl)-3-methyl-benzamide
• CAS NO: 315669-99-9
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.2958
• Mol File: 315669-99-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 350.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.172±0.06 g/cm3(Predicted)
• PKA: 13.61±0.70(Predicted)
• CAS DataBase Reference: N-(3-Acetylphenyl)-3-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Acetylphenyl)-3-methylbenzamide(315669-99-9)
• EPA Substance Registry System: N-(3-Acetylphenyl)-3-methylbenzamide(315669-99-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 315669-99-9(Hazardous Substances Data)

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 
• 99-04-7 m-Toluic acid 
• 1711-06-4 3-Methylbenzoyl chloride 

Downstream Products

• 1349690-83-0 N-(3-((E)-3-(3-bromo-2,4,6-trimethoxyphenyl)acryloyl)phenyl)-3-methylbenzamide 

Relevant articles and documents

HETEROARYL COMPOUNDS AS KINASE INHIBITOR

Provided herein are heteroaryl compounds of formula (I) having activity on a receptor protein tyrosine kinase, wherein R 1, R 2, R 3, A, Q, Z, X and W are set forth in the description, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof.

Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics

Claisen-Schmidt condensation of 3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl) -2,4,5-trimethoxybenzaldehyde 3 and various aromatic, heterocyclic and alicyclic amides of 3-aminoacetophenone 6(as) afforded novel curcumin mimics. All the synthesized compounds

Synthesis and biological evaluation of novel curcumin analogues as anti-inflammatory, anti-cancer and anti-oxidant agents

A series of novel curcumin analogues 5a- m were synthesized by Claisen-Schmidt condensation of various aromatic and heteroaromatic amides of 3-aminoactophenones 4a-m with 3-bromo-2,4,6-trimethoxybenzaldehyde and characterized by IR, 1H NMR and mass spectroscopic analysis and were evaluated for anti-inflammatory, anti-cancer and anti-oxidant activity. Out of the 13 synthesized compounds, compounds 5f, 5j and 5m were excellent inhibitors of TNF-α and IL-6. Compounds 5c, 5e, 5b and 5d showed potent COX-2 inhibition, compounds 5d and 5f have shown good trypsin inhibition and compounds 5e, 5g and 5c exhibited excellent β-glucuronidase inhibition. Compounds 5l and 5m showed potent anti-cancer activity against selected five human cancer cell lines. All the compounds exhibited moderate free radical scavenging activity, while compounds 5a and 5m were excellent OH radical scavengers. Springer Science+Business Media, LLC 2011.