31577-25-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(bromomethyl)-4-chloro-1-nitrobenzene is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique structure allows for the creation of a wide range of organic compounds and medicines, contributing to the development of new treatments and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(bromomethyl)-4-chloro-1-nitrobenzene serves as a key intermediate. Its presence of functional groups, such as the nitro, chloro, and bromomethyl groups, enables it to participate in various chemical reactions, facilitating the synthesis of complex organic molecules for different applications.

InChI:InChI=1/C7H5BrClNO2/c8-4-5-3-6(9)1-2-7(5)10(11)12/h1-3H,4H2

Upstream product

• 5367-28-2 5-chloro-2-nitrotoluene 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 73033-58-6 5-chloro-2-nitrobenzyl alcohol 

Downstream Products

• 85062-28-8 (5-Chloro-2-nitro-benzyl)-(4-methoxy-benzyl)-amine; hydrochloride 
• 85062-45-9 6-Chloro-3-(4-methoxy-benzyl)-3,4-dihydro-quinazolin-2-ylamine; hydrobromide 
• 85062-65-3 7-Chloro-4-(4-methoxy-benzyl)-4,5-dihydro-imidazo[1,2-a]quinazolin-2-one; hydrochloride 
• 748806-34-0 (5-chloro-2-nitro-benzylsulfanyl)-acetic acid 
• 748806-06-6 3-[(5-chloro-2-nitro-benzyl)-amino]-propionic acid methyl ester 
• 1290617-51-4 tert-butyl 5-chloro-N-(diphenylmethylidene)-2-nitro-L-phenylalaninate 
• 569328-82-1 4-chloro-2-methoxymethyl-1-nitro-benzene 
• 3770-50-1 2-carbethoxyindole 

Relevant academic research and scientific papers

3-OXAZOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention relates to a novel 3-indazolinone compound that regulates or inhibits the activity of indoleamine 2,3-dioxygenase (IDO), the method for the preparation thereof and the use thereof in medicine. In particular, the present invention relates to a compound represented by the general formula (I) and a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof, a method for treating or preventing IDO-mediated diseases, especially tumors, by use of the compound or a pharmaceutically acceptable salt thereof, and a method for preparing the compound or a pharmaceutically acceptable salt thereof. The present invention further relates to use of the compound or a pharmaceutically acceptable salt thereof or a composition comprising the compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for treating or preventing IDO-mediated diseases, especially tumors.Wherein the substituents of the general formula (I) are defined the same as that in the specification.

Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Tandem catalytic oxidative deacetylation of acetoacetic esters and heteroaromatic cyclizations

One pot syntheses of furan, thiophene, and pyrrole were accomplished by oxidative deacetylation using Mn(iii)/Co(ii) catalysts and the Paal-Knorr reaction from 1,5-dicarbonyl compounds, which are prepared from the conjugate addition of ethyl acetoacetate to α,β-unsaturated carbonyl compounds. The oxidative deacetylation and reductive cyclization of β-ketoesters derived from ethyl acetoacetate and o-nitrobenzyl bromides efficiently produced diversely substituted indoles. This journal is

Rh2(II)-catalyzed selective aminomethylene migration from styryl azides

Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.

HETEROCYCLIC SULFONAMIDES AS INHIBITORS OF TRANSFER RNA SYNTHETASE FOR USE AS ANTIBACTERIAL AGENTS

The present invention provides aromatic sulphonamides as tRNA synthetase inhibitors and process for their synthesis, pharmaceutical composition and method for treatment. Compounds disclosed can be used as antibacterial agents for the treatment or prevention of conditions caused by or contributed by aerobic and anaerobic Gram-positive pathogens, more particularly against bacterium, for example Staphylococcus, Enterococci and Streptococci. Compounds disclosed are used in particular for the treatment of skin and soft tissue infection, Formula (I)

Methods of Synthesizing 2-Substituted-1,4-Benzenediamine

Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution.

A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction

We describe a generalized approach to stereocontrolled synthesis of substituted cyclic hydroxamic acids (3-amino-1-hydroxy-3,4-dihydroquinolinones) by selective reduction of substituted 2-nitrophenylalanine substrates. Compounds in this series have antibacterial properties and have also recently been reported as KAT II inhibitors. The key nitrophenyl alanine intermediates are prepared enantioselectively in excellent yield by phase transfer catalyzed alkylation of the corresponding nitrobenzyl bromides. The scope and limitations of the reductive cyclization transformation have been explored with attention to the effects of substitution pattern and electronics on reaction efficiency and byproduct formation. In addition, a novel activated trifluoroethyl ester cyclization strategy has been developed as an alternate approach to the most sterically demanding systems in this series.

Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof

The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.