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316-42-7

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Product FOB Price Min.Order Supply Ability Supplier
Emetine 2HCl 316-42-7
Cas No: 316-42-7
No Data No Data No Data Hunan Russell Chemicals Technology Co.,Ltd Contact Supplier
Emetine 2HCl
Cas No: 316-42-7
No Data No Data No Data Pure Chemistry Scientific Inc. Contact Supplier

316-42-7 Usage

Uses

Anti-amebic.

Purification Methods

It crystallises from MeOH/Et2O, MeOH or Et2O/EtOAc. The free base has m 104-105o, and the (-)-phenylthiourea derivative has m 220-221o (from EtOAc/pet ether, [] D -29.3o (CHCl3)). IR: 3413 (OH) and 2611 (NH+) cm-1; UV at 230nm ( 16 200) and 282nm ( 6 890) max max [Brossi et al. Helv Chim Acta 42 1515 1959, Barash et al. J Chem Soc 3530 1959]. [Beilstein 23 III/IV 3419.]

Air & Water Reactions

Water soluble.

Chemical Properties

white powder or crystals

Fire Hazard

When heated to decomposition, EMETINE DIHYDROCHLORIDE emits very toxic fumes of chlorides, hydrogen chloride and oxides of nitrogen. Turns yellow on exposure to light or heat

References

https://www.scbt.com/scbt/product/emetine-dihydrochloride-316-42-7
http://www.biovision.com/emetine-dihydrochloride.html
https://pubchem.ncbi.nlm.nih.gov/compound/3068143#section=Top

General Description

Clusters of needles after drying at 221°F. Turns yellow on exposure to light or heat. An injectable form of emetine, an anti amebic. Emetine is the active ingredient of ipecac.

Health Hazard

EMETINE DIHYDROCHLORIDE is highly toxic orally. It is an eye irritant. (Non-Specific -- Emetine) Emetine is classified as extremely toxic. Probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and one teaspoon for a 150-lb person.

Reactivity Profile

When heated to decomposition, EMETINE DIHYDROCHLORIDE emits very toxic fumes of chlorides, hydrogen chloride and oxides of nitrogen. Turns yellow on exposure to light or heat [EPA, 1998].

Description

As the principal alkaloid of ipecac, Emetine dihydrochloride is derived from Uragoga ipecacuanha ground roots, which is used in the treatment of amebiasis. It can  also be used as an emetic to induce vomiting.
Emetine dihydrochloride functions by inhibiting ribosome movement along mRNA, which results in irreversibly blocking protein synthesis in eukaryotic cells  instead of prokaryotic cells. Besides, it has been proved that it can induce hypotension through blocking adrenoreceptors.
InChI:InChI=1/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24?,25?;;/m0../s1

316-42-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1235004)  Emetine hydrochloride  United States Pharmacopeia (USP) Reference Standard 316-42-7 1235004-300MG 4,326.66CNY Detail

316-42-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name EMETINE DIHYDROCHLORIDE

1.2 Other means of identification

Product number -
Other names Emetin-Dihydrochlorid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:316-42-7 SDS

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