3161-11-3Relevant academic research and scientific papers
Strategies and synthetic methods directed toward the preparation of libraries of substituted isoquinolines
Awuah, Emelia,Capretta, Alfredo
supporting information; experimental part, p. 5627 - 5634 (2010/11/03)
Strategies for the production of substituted isoquinoline libraries were developed and explored. Routes involving microwave-assisted variants of the Bischler-Napieralski or Pictet-Spengler reaction allowed for cyclization of substituted β-arylethylamine derivatives. The dihydroisoquinolines and tetrahydroisoquinolines thus generated could then be oxidized to their corresponding isoquinoline analogues. An alternate strategy, however, involving the preparation and activation of isoquinolin-1(2H)-ones is demonstrated to be a more practical, rapid, and efficient route to C1- and C4-substituted isoquinoline libraries.
