316146-27-7

Basic information

• Product Name: N-(4-bromophenyl)-3-phenylpropanamide
• Synonyms: N-(4-bromophenyl)-3-phenylpropanamide;N-(4-Bromophenyl)-benzenepropanamide;Bedaquiline Impurity C;N-(4-Bromo-phenyl)-3-phenyl-propionamide
• CAS NO: 316146-27-7
• Molecular Formula: C₁₅H₁₄BrNO
• Molecular Weight: 304.18176
• Mol File: 316146-27-7.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 473.2 °C at 760 mmHg
• Flash Point: 240 °C
• Appearance: /
• Density: 1.408 g/cm³
• Vapor Pressure: 4.02E-09mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Most solvents
• PKA: 13.88±0.70(Predicted)
• CAS DataBase Reference: N-(4-bromophenyl)-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)-3-phenylpropanamide(316146-27-7)
• EPA Substance Registry System: N-(4-bromophenyl)-3-phenylpropanamide(316146-27-7)

Safety Data

• Hazardous Substances Data: 316146-27-7(Hazardous Substances Data)

Usage

Chemical Properties

N-(4-bromophenyl)-3-phenylpropanamide is White Solid

Uses

N-(4-bromophenyl)-3-phenylpropanamide is a reactant used in the preparation of quinoline derivatives as antitubercular agent and antibacterial agents.

InChI:InChI=1/C15H14BrNO/c16-13-7-9-14(10-8-13)17-15(18)11-6-12-4-2-1-3-5-12/h1-5,7-10H,6,11H2,(H,17,18)

Upstream product

• 100-42-5 styrene 
• 2617-78-9 N-(4-bromophenyl)formamide 
• 151418-18-7 Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid 
• 106-40-1 4-bromo-aniline 
• 501-52-0 3-Phenylpropionic acid 
• 90878-19-6 phenethylmagnesium chloride 
• 2493-02-9 4-bromophenyl isocyanate 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 33912-40-2 1-(4-bromophenyl)-4-phenylazetidin-2-one 
• 843663-66-1 bedaquiline 
• 1431162-92-3 1-(4-bromophenyl)-3,4-dihydroquinolin-2(1H)-one 
• 924632-90-6 (±)-3-bromo-3-(bromo(phenyl)methyl)-2-methoxyquinoline 
• 1228594-68-0 (1S,2R)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-(6-bromo-2-chloro-quinolin-3-yl)-butan-2-ol 
• 1228594-69-1 (1R,2S)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-(6-bromo-2-chloro-quinolin-3-yl)-butan-2-ol 
• 1219721-55-7 N-(4-(1H-pyrazol-4-yl)phenyl)-3-phenylpropanamide 
• 654655-68-2 3-benzyl-6-bromo-2-chloro-quinoline 
• 654655-69-3 3-benzyl-6-bromo-2-methoxyquinoline 
• 654655-80-8 1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 
• 654653-93-7 rac-(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-2-(1-naphthyl)-1-phenylbutan-2-ol 
• 654653-93-7 (6-bromo-2-memoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol 

Relevant articles and documents

Visible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes

We describe an efficient photoredox system, relying on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes. In this methodology the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, giving access to a large variety of useful building blocks and high-value molecules such as amides and unsymmetrical ketones from simple starting materials.

Copper-Catalyzed Oxidative Benzylic C(sp3)?H Cyclization for the Synthesis of β-Lactams

β-Lactams are important structural motifs because of their ubiquity in natural products and pharmaceuticals. We report herein a Cu-catalyzed intramolecular oxidative C(sp3)?H amidation for the synthesis of β-lactams using tBuOOtBu. This method

Synthesis of Acetaminophen Analogues Containing α-Amino Acids and Fatty Acids for Inhibiting Hepatotoxicity

Acetaminophen is a popular antipyretic analgesic medicine that has weaker anti-inflammatory properties and lower incidence of side effects than nonsteroidal anti-inflammatory drugs (NSAIDs). However, acetaminophen causes hepatotoxicity due to the reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI). We have obtained acetaminophen analogues in 57-99percent yields by using aniline derivatives with protected α-amino acids and fatty acids via the corresponding mixed carbonic carboxylic anhydrides in aqueous MeCN. We have also succeeded in synthesizing AM404 analogues in 76-97percent yields, which are expected to be promising candidates for reducing hepatotoxicity.