316173-87-2

Upstream product

• 1165952-91-9 cyclohexa-1,3-diene 
• 182160-08-3 (S)-3-acetoxyamino-2-(1-hydroxy-2,2-dimethylprop-1-yl)-quinazolin-4(3H)-one 
• 182160-10-7 (S)-3-amino-2-(1-hydroxy-2,2-dimethylprop-1-yl)-quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Aziridination of cyclic dienes with enantiopure 3-acetoxyamino-quinazolin-4(3H)-ones

Aziridination of cyclopentadiene and cyclohepta-1,3-diene with (S)-3-acetoxyamino-2-(3-hydroxy-2,2-dimethyl- propyl)quinazolin-4(3H)-one 6 (Q1NHOAc) in the presence of titanium(IV) tert-butoxide in dichloromethane takes place highly diastereose

Diastereoselective aziridination of cyclic dienes with 3-acetoxyaminoquinazolin-4(3H)-ones: Competitive formation of insertion products from cyclohexadienes

Aziridination of cyclopentadiene and cycloheptadiene with 3-acetoxyamino-2-[(S)-1-hydroxy-2,2-dimethylpropyl]quinazolin-4(3H)-one 1 in the presence of titanium(IV) tert-butoxide gave the corresponding vinyl aziridines highly diastereoselectively: the corresponding aziridination product of cyclohexa-1,3-diene is formed less diastereoselectively and is accompanied by a by-product 9 from formal insertion into an allylic C-H bond, a previously unobserved reaction type for 3-acetoxyaminoquinazolinones. (C) 2000 Elsevier Science Ltd.