31644-05-0Relevant academic research and scientific papers
Synthesis and resolution of the benzomorphan-based kappa opioid agonist bremazocine
Thomas, James B.,Brieaddy, Lawrence E.,Boldt, Karl G.,Perretta, Carin,Carroll, F. Ivy
, p. 1481 - 1484 (2008/02/08)
An efficient synthesis of racemic bremazocine hydrochloride salt was developed. The racemic material was resolved using (+)- and (-)-3- bromocamphorsulfonic acid ammonium salt to give optically pure samples of (-)- and (+)-bremazocine. Georg Thieme Verlag
2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives
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, (2008/06/13)
6,7-BENZOMORPHAN DERIVATIVES HAVING ANALGESIC AND MORPHINE-ANTAGONISTIC PROPERTIES ARE OF THE FORMULA STR1 in which the substituents R are either lower alkyl groups or groups which, together with the carbon atom to which they are bonded, form a cycloaliphatic ring, and the substituents R1, R2 and R 3 may or may not be made and, if made, R1 represents either a hydrogen atom or an alkyl, haloalkyl, alkenyl, alkinyl, aralkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl or cycloalkylidine-alkyl group, R 2 is an alkyl, aryl, heteroaryl or aralkyl group, and R 3 is a hydrogen atom or an hydroxy, alkoxy, alkoxy-alkoxy or acyloxy group. Such 6,7-benzomorphans may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. There are also disclosed methods for producing such 6,7-benzomorphan derivatives, and intermediates useful in such production.
