31648-54-1

Basic information

• Product Name: 3-CBZ-AMINOPIPERIDINE HCL
• Synonyms: PIPERIDIN-3-YL-CARBAMIC ACID BENZYL ESTER;3-N-CBZ-AMINO-PIPERIDINE;3-BENZYLOXYCARBONYLAMINO-PIPERIDINE;3-CBZ-AMINOPIPERIDINE;3-CBZ-AMINOPIPERIDINE HCL;3-N-Cbz-aminopiperidine hydrochloride;Carbamic acid, 3-piperidinyl-, phenylmethyl ester (9CI);3-Cbz-aminopiperidinehydrochloride
• CAS NO: 31648-54-1
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 270.76
• Product Categories: N-CBZ;pharmacetical
• Mol File: 31648-54-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 396.3 °C at 760 mmHg
• Flash Point: 193.475 °C
• Appearance: /
• Density: 1.139 g/cm³
• Vapor Pressure: 1.73E-06mmHg at 25°C
• CAS DataBase Reference: 3-CBZ-AMINOPIPERIDINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CBZ-AMINOPIPERIDINE HCL(31648-54-1)
• EPA Substance Registry System: 3-CBZ-AMINOPIPERIDINE HCL(31648-54-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 31648-54-1(Hazardous Substances Data)

Usage

General Description

3-CBZ-AMINOPIPERIDINE HCL, also known as N-Carbobenzyloxyaminopiperidine hydrochloride, is a chemical compound with the molecular formula C14H21ClN2O2. It is a piperidine derivative with a benzyl carbamate group attached to the amino group. 3-CBZ-AMINOPIPERIDINE HCL is used in the synthesis of pharmaceuticals and as a building block in organic chemistry. It has potential applications in medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases and conditions. The hydrochloride salt form of 3-CBZ-AMINOPIPERIDINE is a white to off-white crystalline powder that is soluble in water and alcohols. It is important to handle and use this chemical with proper safety precautions in a controlled laboratory setting.

InChI:InChI=1/C13H18N2O2/c16-13(15-12-7-4-8-14-9-12)17-10-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2,(H,15,16)/p+1/t12-/m0/s1

Upstream product

• 501-53-1 benzyl chloroformate 
• 144243-24-3 tert‐butyl 3‐aminopiperidine‐1‐carboxylate 
• 183207-70-7 3(R)-Benzyloxycarbonylamino-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone

The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: STR1 wherein R1, R4, R5, A,X,Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di and tri substituted piperidines, pyrrolidines, and hexahydro-1H-azepines as the active ingredient thereof are also disclosed.