31697-20-8 Usage
General Description
5-(Methylthio)-6-azauracil is a chemical compound with the molecular formula C5H6N2OS. It is a derivative of uracil and is often used in the synthesis of pharmaceuticals and as a biochemical tool in research. 5-(METHYLTHIO)-6-AZAURACIL is known for its potential antitumor and antiviral properties, making it of interest in medical research. It has also been studied for its potential to inhibit ribonucleotide reductase, an enzyme involved in DNA synthesis, which could have implications for cancer treatment. Additionally, 5-(methylthio)-6-azauracil has been investigated for its potential to inhibit the replication of RNA viruses, including HIV and influenza. Overall, this compound has potential applications in both medical and biochemical research, particularly in the development of new drugs and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 31697-20-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,6,9 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 31697-20:
(7*3)+(6*1)+(5*6)+(4*9)+(3*7)+(2*2)+(1*0)=118
118 % 10 = 8
So 31697-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N3O2S/c1-10-3-2(8)5-4(9)7-6-3/h1H3,(H2,5,7,8,9)
31697-20-8Relevant articles and documents
Anticoccidial derivatives of 6 azauracil. I. Enhancement of activity by benzylation of nitrogen 1. Observations on the design of nucleotide analogues in chemotherapy
Mylari,Miller,Howes Jr.,Figdor,Lynch,Koch
, p. 475 - 483 (2007/10/09)
Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to augment its anticoccidial activity fourfold. The high potency of 1-benzyl-6-azauracil is ascribed to a combination of intrinsic activity, efficient oral absorption, and a moderate rate of excretion. Metabolism experiments using 1-benzyl-6-azauracil labeled with 14C in the heterocycle and (separately) in the side chain showed that, in the drug accounted for, no cleavage had occurred. Additional activity increases were achieved by introducing small, electron-withdrawing substituents in the meta and/or para position(s) of the benzyl group. One of the most active derivatives, 1-(3-cyanobenzyl)-6-azauracil, is about 16 times as potent as 6-azauracil.
