31697-20-8 Usage
Uses
Used in Pharmaceutical Synthesis:
5-(METHYLTHIO)-6-AZAURACIL is utilized as a key intermediate in the synthesis of various pharmaceuticals, leveraging its unique chemical properties to contribute to the development of novel drug molecules.
Used in Biochemical Research:
As a biochemical tool, 5-(METHYLTHIO)-6-AZAURACIL is employed in research to study the mechanisms of DNA synthesis and viral replication, providing insights into the fundamental biological processes and aiding in the discovery of new therapeutic targets.
Used in Cancer Treatment Development:
5-(METHYLTHIO)-6-AZAURACIL is used as a potential antitumor agent in the development of cancer treatments, targeting ribonucleotide reductase to disrupt DNA synthesis and inhibit tumor growth.
Used in Antiviral Drug Development:
In the field of antiviral research, 5-(METHYLTHIO)-6-AZAURACIL is applied as a candidate for the creation of new antiviral drugs, particularly for the inhibition of RNA virus replication, offering a potential defense against viral infections such as HIV and influenza.
Used in Drug Design and Medicinal Chemistry:
5-(METHYLTHIO)-6-AZAURACIL serves as a structural motif in drug design, where its unique features can be exploited to create new molecules with enhanced pharmacological properties, contributing to the advancement of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 31697-20-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,6,9 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 31697-20:
(7*3)+(6*1)+(5*6)+(4*9)+(3*7)+(2*2)+(1*0)=118
118 % 10 = 8
So 31697-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N3O2S/c1-10-3-2(8)5-4(9)7-6-3/h1H3,(H2,5,7,8,9)
31697-20-8Relevant academic research and scientific papers
Anticoccidial derivatives of 6 azauracil. I. Enhancement of activity by benzylation of nitrogen 1. Observations on the design of nucleotide analogues in chemotherapy
Mylari,Miller,Howes Jr.,Figdor,Lynch,Koch
, p. 475 - 483 (2007/10/09)
Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to augment its anticoccidial activity fourfold. The high potency of 1-benzyl-6-azauracil is ascribed to a combination of intrinsic activity, efficient oral absorption, and a moderate rate of excretion. Metabolism experiments using 1-benzyl-6-azauracil labeled with 14C in the heterocycle and (separately) in the side chain showed that, in the drug accounted for, no cleavage had occurred. Additional activity increases were achieved by introducing small, electron-withdrawing substituents in the meta and/or para position(s) of the benzyl group. One of the most active derivatives, 1-(3-cyanobenzyl)-6-azauracil, is about 16 times as potent as 6-azauracil.
