31698-94-9Relevant academic research and scientific papers
Direct synthesis of 2,5-disubstituted oxazoles through an iodine-catalyzed decarboxylative domino reaction
Xu, Wei,Kloeckner, Ulrich,Nachtsheim, Boris J.
, p. 6065 - 6074 (2013/07/26)
An efficient iodine-catalyzed synthesis of highly substituted oxazoles is presented. Starting from readily available aryl methyl ketones, β-keto esters, or styrenes, in combination with α-amino acids as amine-containing coupling partners, the corresponding 2-alkyl-5-aryl- substituted oxazoles were obtained in up to 80% yield via a decarboxylative domino reaction.
