317-60-2

Usage

Uses

Used in Organic Synthesis:
ETHYL 4-TRIFLUOROMETHYLINDOLE-2-CARBOXYLATE is used as a building block in organic synthesis for the creation of various biologically active molecules. Its unique structure allows it to be a versatile component in the synthesis of complex organic compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, ETHYL 4-TRIFLUOROMETHYLINDOLE-2-CARBOXYLATE is utilized for its potential pharmaceutical applications. Its properties are being studied to explore its use in developing new drugs and therapies.
Used in Pesticide or Herbicide Development:
ETHYL 4-TRIFLUOROMETHYLINDOLE-2-CARBOXYLATE has been studied for its potential use as a pesticide or herbicide. Its chemical properties may offer advantages in controlling pests or unwanted plant growth, contributing to agricultural and environmental management solutions.

Upstream product

• 2261-08-7 (E)-ethyl 2-(2-(3-trifluoromethylphenyl)hydrazin-1-ylidene)propanoate 
• 200345-63-7 (Z)-2-Azido-3-(2-trifluoromethyl-phenyl)-acrylic acid ethyl ester 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 200345-65-9 2-Azido-3-hydroxy-3-(2-trifluoromethyl-phenyl)-propionic acid ethyl ester 

Downstream Products

• 220677-31-6 Ethyl N-(3,4-dichlorobenzyl)-4-trifluoromethylindole-2-carboxylate 
• 103027-96-9 Indol-2,4-dicarbonsaeure 
• 317-59-9 4-(trifluoromethyl)-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful

Monocyte chemoattractant protein-1 inhibitor compounds

The invention concerns the use of a compound of the formula (I) in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, in the treatment of a disease or condition mediated by monocyte chemoattractant protein-1 (MCP-1). Certain of the components of formula (I) are novel and are provided, together with pharmaceutical compositions thereof, as further features of the invention.

New findings on the hemetsberger-knittel reaction (synthetic studies on indoles and related compounds. XLIII(1))

In the Hemetsberger-Knittel reaction for indole synthesis, the intermediate ethyl 2-azido-3-hydroxy-3-aryl-propionate (4) was found to be formed in the reaction of arylaldehyde 1 with ethyl azidoacetate at a lower temperature (-30°C) as the main product,