317-79-3

Basic information

• Product Name: 2-Bromo-1-fluoronaphthalene
• Synonyms: 2-Bromo-1-fluoronaphthalene
• CAS NO: 317-79-3
• Molecular Formula: C₁₀H₆BrF
• Molecular Weight: 225.06
• Mol File: 317-79-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: -4--2 °C
• Boiling Point: 282.805 °C at 760 mmHg
• Flash Point: 128.438 °C
• Appearance: /
• Density: 1.564 g/cm³
• Vapor Pressure: 0.00561mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Bromo-1-fluoronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1-fluoronaphthalene(317-79-3)
• EPA Substance Registry System: 2-Bromo-1-fluoronaphthalene(317-79-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 317-79-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-fluoronaphthalene is a chemical compound with the molecular formula C10H7BrF. It is a derivative of naphthalene, with a carbon ring structure and bromine and fluorine substituents. 2-Bromo-1-fluoronaphthalene is used in organic synthesis as a building block for the creation of more complex molecules. It is also used as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. 2-Bromo-1-fluoronaphthalene is a versatile compound that is utilized in a range of industrial and research applications due to its chemical reactivity and potential for creating new chemical products.

InChI:InChI=1/C10H6BrF/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H

Upstream product

• 321-38-0 1-Fluoronaphthalene 
• 771-14-2 2-bromonaphthalen-1-amine 

Downstream Products

• 13772-59-3 3-bromo-1-fluoronaphthalene 
• 1084741-16-1 C₂₄H₂₁FN₄ 
• 143901-96-6 1-fluoro-2-naphthalenecarbaldehyde 
• 874907-58-1 1,1'-difluoro-3,3'-bis(diphenylphosphoryl)-2,2'-binaphthyl 
• 874907-50-3 1,1'-difluoro-2,2'-binaphthyl-3,3'-dicarbaldehyde 
• 874907-49-0 3,3'-dibromo-1,1'-difluoro-2,2'-binaphthyl 
• 874907-57-0 (1-fluoronaphth-3-yl)diphenylphosphane oxide 
• 874907-48-9 3-bromo-1-fluoro-2-iodonaphthalene 
• 23683-29-6 2-Cyan-1-fluor-naphthalin 
• 737-71-3 1-fluoro-[2,2']binaphthyl 

Relevant articles and documents

The abnormal behavior of an atropisomer: 3,3′-dibromo-1,1′- difluoro-2,2′-binaphthyl reacting with alkyllithium compounds

1-Fluoro-2-(triethylsilyl)naphthalene (1) and other 1-fluoronaphthalenes bearing a metalation-resistant substituent at the 2-position proved to be totally inert toward base attack. 3-Bromo-1-fluoronaphthalene (6), readily prepared from the 2-bromo isomer 5 by deprotonation-triggered heavy halogen migration, was converted into 3,3′-dibromo-1,1′-difluoro-2,2′- binaphthyl (8) by consecutive treatment with lithium diisopropylamide, copper(II) bromide and nitrobenzene. The dilithiated intermediate generated from the atropisomer 8 by treatment with 2 equiv. of butyllithium reacted with a variety of electrophiles to afford products such as the diacid 12 or the bis(phosphanes) 14 and 15 in high yields. The latter compound was also obtained in a straightforward manner from (4-fluoro-2-naphthyl)diphenylphosphane oxide (16). Unexpectedly, neither the 3,3′-dibromobinaphthyl 8 nor its 3,3′-diiodo analogue 18 were amenable to a unilateral but only to a double-sided halogen/metal permutation. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.