317366-38-4Relevant academic research and scientific papers
Synthesis of achiral α,α-bis(aminomethyl)-β-alanines and their use in the preparation of branched β-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on solid support
Heinonen, Petri,Rosenberg, Jaana,Loennberg, Harri
, p. 3647 - 3652 (2007/10/03)
Three achiral branching units 1-3 derived from α,α-bis(aminomethyl)-β-alanine were synthesized and evaluated in the construction of branched and sterically compact β-peptide conjugates on a solid support. Several peptide conjugates bearing an N-alkylated 1,2,3,4-tetrahydroisoquinoline moiety were prepared to demonstrate the applicability of the branching units in a solid phase peptide synthesis. The most useful building block 3 incorporated Boc-protected aminomethyl side chains at the α-carbon of N-phthaloyl-β-alanine.
