Amyloid beta-protein (42-1) trifluoroacetate is a synthetic peptide that represents the 42-1 fragment of the amyloid beta-protein, a key component implicated in the development of Alzheimer's disease. This peptide is specifically designed to mimic the behavior of the amyloid beta-protein in the human body, allowing researchers to study its aggregation and toxicity. The trifluoroacetate salt form of the peptide enhances its solubility and stability, facilitating its use in laboratory settings. It serves as a valuable tool for understanding the molecular mechanisms underlying Alzheimer's disease and for developing potential therapeutic interventions.
317366-82-8
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Basic information
- Product Name: AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE
- Synonyms: ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA TRIFLUOROACETATE;ALA-ILE VAL-VAL-GLY-GLY-VAL-MET-LEU-GLY-ILE-ILE-ALA-GLY-LYS-ASN-SER-GLY-VAL-ASP-GLU-ALA-PHE-PHE-VAL-LEU-LYS-GLN-HIS-HIS-VAL-GLU-TYR-GLY-SER-ASP-HIS-ARG-PHE-GLU-ALA-ASP TRIFLUOROACETATE;AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE;AMYLOID BETA-PROTEIN (HUMAN, 1-42) TRIFLUOROACETATE;PEPTIDE WITH REVERSED SEQUENCE OF AMYLOID BETA-PROTEIN (HUMAN, 1-42) TRIFLUOROACETATE;Amyloid β-Protein (42-1);b-Amyloid (42-1);Amyloid β-peptide (42-1) (human)
- CAS NO:317366-82-8
- Molecular Formula: C203H311N55O60S
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Neuroscience;proteins
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE(CAS DataBase Reference)
- NIST Chemistry Reference: AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE(317366-82-8)
- EPA Substance Registry System: AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE(317366-82-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 317366-82-8(Hazardous Substances Data)
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317366-82-8 Usage
Uses
Used in Alzheimer's Disease Research:Amyloid beta-protein (42-1) trifluoroacetate is used as a research tool for studying the aggregation and toxicity of amyloid beta-protein, which is a critical factor in the development of Alzheimer's disease. It helps scientists to investigate the molecular mechanisms that lead to neuronal dysfunction and the progression of the disease.
Used in Pharmaceutical Development:
In the pharmaceutical industry, amyloid beta-protein (42-1) trifluoroacetate is used as a target for developing potential therapeutic interventions for Alzheimer's disease. By understanding how this peptide forms toxic aggregates, researchers can design drugs that prevent or reverse these effects, offering new treatment options for patients.
Used in Diagnostics:
Amyloid beta-protein (42-1) trifluoroacetate can also be used in the development of diagnostic tools for Alzheimer's disease. Its ability to form aggregates similar to those found in the brains of Alzheimer's patients makes it a useful marker for detecting the presence of the disease at an early stage.
Used in Toxicology Studies:
In toxicology, amyloid beta-protein (42-1) trifluoroacetate is used to study the effects of various compounds on the aggregation and toxicity of amyloid beta-protein. This can help in identifying potential neuroprotective agents or understanding the mechanisms of action of certain drugs that may have adverse effects on the nervous system.
Overall, amyloid beta-protein (42-1) trifluoroacetate plays a crucial role in advancing our understanding of Alzheimer's disease and in the development of new treatments and diagnostic tools for this debilitating condition.
Check Digit Verification of cas no
The CAS Registry Mumber 317366-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,7,3,6 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.Calculate Digit Verification of CAS Registry Number 317366-82:
(8*3)+(7*1)+(6*7)+(5*3)+(4*6)+(3*6)+(2*8)+(1*2)=148
148 % 10 = 8
So 317366-82-8 is a valid CAS Registry Number.
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AMYLOID BETA-PROTEIN (42-1) TRIFLUOROACETATE
