3176-53-2Relevant academic research and scientific papers
Synthesis, characterization and fungitoxicity of 3,4,6-triayl-striazolo [3,4-b]-1,3,4-thiadiazolo [1,3,5]-triazine-5-thiones
Mishra, Rakesh Mani
experimental part, p. 227 - 232 (2012/01/07)
In the present work 3,4,6-triayl-s-triazolo [3,4-b]-1,3,4-thiadiazolo [1,3,50-triazine-5-thiones (IVan) were synehsized by 4+2 cycloaddition of 6-arylidine amino-3-aryl-s-triazolo [3,4-b]-1,3,4-thiadiazoles (IIIa-n) are arylisothiocynate in dry tolune as solvent. 6-Arylidine amino-3-aryl-s-triazolo [3,4-b]-1,3,4-thiadiazoles (IIIa-n) were prepared from aromatic aldehyde refluxing in absolute ethanol with 6-amino-3-aryl-s-triazole [3,4-b]-1,3,4-thiadiazoles (IIa-g), which are prepared from 3-aryl, 4-amino-5-mercaptos-triazole (Ia-g) by treating it with cyanogen bromide in ethanol. Starting material 3-aryl, 4-amino-5-mercapto-s-triazoles (Ia-g) wre prepred in excellent yield following the method of Ried and Heindel1. The reaction sequence leading to the formation of titled compounds are given in the scheme 1. All the synthesized fourteen titled compounds were well characterized by their analytical and spectral data. Fungitoxicity of titled compounds (IVa-n) have been evaluated against two fungal species i.e. Helminthosporium orayzee and Alternaria solanai.
Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives
Eweiss, N. F.,Bahajaj, A. A.
, p. 1173 - 1182 (2007/10/02)
The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.
