317832-08-9

Basic information

• Product Name: 3-(diphenylphosphinyl)-N-methylindole
• Synonyms: 3-(diphenylphosphinyl)-N-methylindole
• CAS NO: 317832-08-9
• Molecular Weight: 331.354
• Mol File: 317832-08-9.mol

Chemical Properties

• CAS DataBase Reference: 3-(diphenylphosphinyl)-N-methylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(diphenylphosphinyl)-N-methylindole(317832-08-9)
• EPA Substance Registry System: 3-(diphenylphosphinyl)-N-methylindole(317832-08-9)

Safety Data

• Hazardous Substances Data: 317832-08-9(Hazardous Substances Data)

Upstream product

• 24662-37-1 1-methyl-1H-indole-3-carbonitrile 
• 4559-70-0 Diphenylphosphine oxide 
• 124589-41-9 3-chloro-1-methyl-1H-indole 
• 1079-66-9 chloro-diphenylphosphine 
• 120-72-9 indole 
• 317832-05-6 (1H-indol-3-yl)diphenylphosphine oxide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Nickel-catalysed P-C bond formation via P-H/C-CN cross coupling reactions

Nickel-catalysed P-H/C-CN cross coupling reactions take place efficiently under mild reaction conditions affording the corresponding sp2C-P bonds. This transformation provides a convenient method for the preparation of arylphosphines and arylphosphine oxides from the readily available P-H compounds and arylnitriles. This journal is

Nickel-catalyzed C-P cross-coupling of diphenylphosphine oxide with aryl chlorides

A novel protocol for the preparation of various diarylphosphine oxide compounds via a Ni-catalyzed cross-coupling of aryl chlorides with R 2P(O)H has been developed. Notably, this process exhibits the following very attractive features: (i) the process is simpler and operates under mild reaction conditions; (ii) the process is generally cheaper in part because the more accessible aryl chloride is used to form the C-P bond; (iii) the process avoids the need for simultaneous preparation and use of Ar 2P(O)M. The Royal Society of Chemistry 2012.

SMALL MOLECULE NEUROPEPTIDE S ANTAGONISTS FOR THE TREATMENT OF ADDICTIVE DISORDERS, MOOD, ANXIETY AND SLEEP DISORDERS

Disclosed are compounds of General Formula I: wherein R1, R2, R3, X and Y are described herein, as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof. Pharmaceutical compositions comprising such compounds, as well as methods of

3,3'-bis(diphenylphosphino)-1,1'-disubstituted-2,2'-biindoles: Easily accessible, electron-rich, chiral diphosphine ligands for homogeneous enantioselective hydrogenation of oxoesters

Racemic (±)-3,3'-bis(diphenylphosphinyl)-1,1'-dimethyl-2,2'-biindole (1c) (N-Me-2-BINPO) and (±)-3,3'-bis(diphenylphosphinyl)-1,1'-bis(methoxymethyl)-2,2'-biindole (1d) (N-MOM-2-BINPO) were synthesized in satisfactory yields following a three-step reaction sequence, starting from indole. Resolution of racemic 1c and 1d was achieved through fractional crystallization of their diastereomeric adducts with optically active dibenzoyl tartaric acids, followed by alkaline decomplexation of the diastereomerically pure salts. Their trichlorosilane reduction gave enantiopure phosphines (+)- and (-)-(1a) (N-Me-2-BINP) and (+)- and (-)-(1b) (N-MOM-2-BINP). The electrochemical oxidative potential of 1a and 1b was found to be 0.52 and 0.60 V, respectively. Both the enantiomers of (1a) were tested as ligands of Ru(II) in asymmetric hydrogenation reactions of α- and β-oxoesters. Reactions were found to be outstandingly fast and enantioselection quite good. Comparative kinetic experiments on the hydrogenation reaction of methyl acetoacetate carried out with 1a, 1c, BINAP, and other biheteroaromatic diphosphines as ligands of Ru(II) demonstrated that all the reactions follow a first-order kinetic. A linear relationship was found between the kinetic constant log and the electrochemical oxidative potential of the diphosphine ligand.