31785-05-4

Basic information

• Product Name: 5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester AldrichCPR;5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;ETHYL 5-AMINO-2-METHYLTHIAZOLE-4-CARBOXYLATE;5-Amino-4-(ethoxycarbonyl)-2-methyl-1,3-thiazole;Ethyl 5-amino-2-methyl-1,3-thiazole-4-carboxylate;5-Amino-2-methyl-thiazole-4-carboxylic;acid ethyl ester
• CAS NO: 31785-05-4
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.23
• EINECS: 1308068-626-2
• Mol File: 31785-05-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 158-159 °C
• Boiling Point: 301.941 °C at 760 mmHg
• Flash Point: 136.409 °C
• Appearance: /
• Density: 1.284 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.38±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(31785-05-4)
• EPA Substance Registry System: 5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(31785-05-4)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 31785-05-4(Hazardous Substances Data)

Usage

General Description

5-Amino-2-methyl-thiazole-4-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H10N2O2S. It is an ethyl ester derivative of 5-amino-2-methylthiazole-4-carboxylic acid. 5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER is used in organic synthesis as a reagent for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Its presence in various products and applications highlights its importance as a versatile intermediate in the synthesis of a wide range of compounds. Additionally, it is known for its potential biological activities, making it a significant molecule in medicinal chemistry research. Overall, 5-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester is a valuable chemical in the field of organic synthesis and pharmaceutical development.

InChI:InChI=1/C7H10N2O2S/c1-3-11-7(10)5-6(8)12-4(2)9-5/h3,8H2,1-2H3

Upstream product

• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 
• 3356-83-0 2-methyl-4-(methylaminocarbonyl)-5-ethoxyoxazole 

Relevant articles and documents

Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor

Focal adhesion kinase (FAK) is a tyrosine kinase with prominent roles in protein scaffolding, migration, angiogenesis, and anchorage-independent cell survival and is an attractive target for the development of cancer therapeutics. However, current FAK inhibitors display dual kinase inhibition and/or significant activity on several kinases. Although multitargeted activity is at times therapeutically advantageous, such behavior can also lead to toxicity and confound chemical-biology studies. We report a novel series of small molecules based on a tricyclic pyrimidothiazolodiazepinone core that displays both high potency and selectivity for FAK. Structure-activity relationship (SAR) studies explored modifications to the thiazole, diazepinone, and aniline "tail,"which identified lead compound BJG-03-025. BJG-03-025 displays potent biochemical FAK inhibition (IC50 = 20 nM), excellent kinome selectivity, activity in 3D-culture breast and gastric cancer models, and favorable pharmacokinetic properties in mice. BJG-03-025 is a valuable chemical probe for evaluation of FAK-dependent biology.

Rearrangement of 4-(Aminothiocarbonyl)oxazoles to 5-Aminothiazoles. Synthetic and MINDO/3 MO Studies

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