31793-29-0

Usage

Chemical Properties

Yellow solid

Upstream product

• 504-24-5 4-aminopyridine 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 39771-28-3 2,4,6-triamino-3,5-dinitropyridine 
• 1305317-28-5 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-4-methoxybenzamide 
• 1305317-27-4 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]acetamide 
• 1305317-26-3 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)acetamide 
• 1305317-29-6 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N,N'-diethyldicarbonimidic diamide 
• 1305317-25-2 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-ethylthiourea 
• 1305317-24-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylthiourea 
• 1305317-22-9 N-[2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]-N'-phenylurea 
• 1305317-20-7 N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea 
• 1305317-19-4 N-(3-chlorophenyl)-N'-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)urea 
• 1305317-18-3 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-(3-methoxyphenyl)urea 
• 1305317-17-2 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-phenylurea 
• 1305317-16-1 N-(2,3-diphenylpyrido[3,4-b]pyrazin-8-yl)-N'-ethylurea 
• 1305317-11-6 8-amino-2,3-bis(4-methoxyphenyl)pyrido[3,4-b]pyrazine 

Relevant academic research and scientific papers

Preparation of novel 2,3,8-trisubstituted pyrido[3,4-b]pyrazines and pyrido[2,3-b]pyrazines

A four-step synthesis of 8-bromo-2,3-disubstituted pyrido[3,4-b]pyrazines and a six-step synthesis of 8-amino-2,3-disubstituted pyrido[3,4-b]pyrazines have been developed. A particularly valuable feature of this synthetic route is the possibility to build

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists based on a 4-piperazinylbenzimidazole template, we sought to investigate the properties of heterocyclic isosteres of the benzimidazole template. We report here the synthesis and biological activity of eight novel scaffolds, including imidazopyridines, benzothiazoles and benzoxazoles. The 2-(4-tert-butylphenyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine ring system was shown to have nanomolar binding potency at the human and rat GnRH receptors as well as functional antagonism in vitro. Additional structure-activity relationships within this series are reported along with a pharmacokinetic comparison to the benzimidazole-based lead molecule.

7-SUBSTITUTED IMIDAZO[4,5-C]PYRIDINE ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE RECEPTOR

The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.