318233-92-0Relevant academic research and scientific papers
Atroposelective sp3 C—H Coupling for Kinetic Resolution of Thioanilide Atropisomers
Jiang, Hua-Jie,Geng, Rui-Long,Wei, Jia-Hui,Gong, Liu-Zhu
supporting information, p. 3269 - 3276 (2021/10/07)
A highly efficient kinetic resolution of racemic thioanilide atropisomers via C(sp3)?H arylation has been achieved by a hybrid palladium catalyst bearing an anionic chiral CoIII-complex and a phosphoramidite ligand, leading to both e
Cu-Catalyzed Intramolecular Amidation of Unactivated C(sp3)-H Bonds to Synthesize N-Substituted Indolines
Pan, Fei,Wu, Bin,Shi, Zhang-Jie
supporting information, p. 6487 - 6490 (2016/05/02)
A copper-catalyzed intramolecular amidation of unactivated C(sp3)-H bonds to construct indoline derivatives has been developed. Such an amidation proceeded well at primary C-H bonds preferred to secondary C-H bonds. The transformation owned a b
A chiral axis due to an acyclic imide-Ar bond: A study of steric effects of acyl groups on racemization
Kondo, Kazuhiro,Iida, Takeko,Fujita, Hiroko,Suzuki, Tomoko,Yamaguchi, Kentaro,Murakami, Yasuoki
, p. 8883 - 8891 (2007/10/03)
Studies on the racemization in a series of optically active compounds 3a-e, including the steric effect of their acyl groups, are described. The first example of optically active compounds 3c and 3d, which possess axial chirality based on an acyclic imide-Ar bond, has been reported. A quite interesting result has been revealed, namely, that 3a bearing a bulky acyl group rather than a relatively small one racemized more easily. To explain this observed phenomenon, 13C NMR experiments and the reaction with benzylamine of 3a-e were undertaken. These results suggested that the t-BuCO-N bond in 3a which racemized easily, is more twisted, compared with the RCO-N bonds in 3b-e which are relatively stable to racemization. Furthermore, the absolute configuration of 3b and 3c has been determined to be R by the CD spectrum and the X-ray crystallographic analysis of racemic 3f has been accomplished. (C) 2000 Published by Elsevier Science Ltd.
