318465-73-5

Basic information

• Product Name: 2-Carboxybenzoyl Amlodipine
• Synonyms: Amlodipine EP Impurity I;2-(2-((4-(2-Chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2;2-Carboxybenzoyl Amlodipine;2-[[2-[[(4RS)-4-(2-Chlorophenyl)-3-(ethoxycarbonyl)- 5-(Methoxycarbonyl)-6-Methyl-1,4-dihydropyridin-2-yl] Methoxy]ethyl]-carbaMoyl]benzoic Acid;2-[[2-[(2-Carboxybenzoyl)aMino]ethoxy]Methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-Methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester;2-(2-((4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(Methoxycarbonyl)-6-Methyl-1,4-dihydropyridin-2-yl)Methoxy)ethylcarbaMoyl)benzoic acid;AMlodipine IMpurity H (EP);AMlodipine EP IMpurity H
• CAS NO: 318465-73-5
• Molecular Formula: C34H35ClN2O11S
• Molecular Weight: 715.1665
• Product Categories: Aromatics;Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 318465-73-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 727.646°C at 760 mmHg
• Flash Point: 393.866°C
• Appearance: /
• Density: 1.306g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 3.49±0.36(Predicted)
• CAS DataBase Reference: 2-Carboxybenzoyl Amlodipine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Carboxybenzoyl Amlodipine(318465-73-5)
• EPA Substance Registry System: 2-Carboxybenzoyl Amlodipine(318465-73-5)

Safety Data

• Hazardous Substances Data: 318465-73-5(Hazardous Substances Data)

Usage

Description

2-Carboxybenzoyl Amlodipine is a chemical compound derived from Amlodipine Besilate (A633500), which is an impurity in the synthesis process of Amlodipine benzenesulfonate. It plays a significant role in the pharmaceutical industry, particularly in the development and production of Amlodipine-based medications.
Used in Pharmaceutical Industry:
2-Carboxybenzoyl Amlodipine is used as an impurity in the process for preparing Amlodipine benzenesulfonate. It is essential for ensuring the purity and quality of the final product, which is a calcium channel blocker used to treat hypertension, angina, and certain heart rhythm disorders.
Additionally, 2-Carboxybenzoyl Amlodipine is identified as Amlodipine EP Impurity H, which indicates its relevance in the European Pharmacopoeia standards for the quality control and regulation of Amlodipine-based medications. This highlights its importance in maintaining the safety and efficacy of these drugs for patients.

InChI:InChI=1/C28H29ClN2O8/c1-4-39-28(36)24-21(15-38-14-13-30-25(32)17-9-5-6-10-18(17)26(33)34)31-16(2)22(27(35)37-3)23(24)19-11-7-8-12-20(19)29/h5-12,23,31H,4,13-15H2,1-3H3,(H,30,32)(H,33,34)