3185-50-0

Upstream product

• 589-87-7 1,4-bromoiodobenzene 
• 73918-56-6 4-Bromophenethylamine 
• 140-29-4 phenylacetonitrile 
• 55-21-0 benzamide 

Downstream Products

• 823236-15-3 7-bromo-1-phenyl-3,4-dihydro-isoquinoline 
• 60739-34-6 4-bromo-5-(4-bromo-phenyl)-2-phenyl-oxazole 
• 96908-21-3 2-phenyl-5-(4-bromophenyl)-5-oxazole 
• 823236-51-7 6-[(E)-2-(1-Phenyl-3,4-dihydro-isoquinolin-7-yl)-vinyl]-naphthalene-2-carbonitrile 
• 823236-18-6 1-phenyl-3,4-dihydro-isoquinoline-7-carbaldehyde 
• 947330-78-1 C₂₈H₂₈N₂O₃ 

Relevant academic research and scientific papers

I2-Catalyzed Oxidative Amidation of Benzylamines and Benzyl Cyanides under Mild Conditions

We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions.

Chitosan: An efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

A novel chitosan-catalyzed transamidation of carboxamides with amines under solvent-free conditions is described. A series of amide derivatives as well as more challenging aryl and alkyl amines with long-chain alkyl substituents could be selectively converted into the corresponding transamidation products, which are frequently found in biologically active compounds and pharmaceuticals. Under similar reaction conditions benzo[d]heterocycles were also obtained via a one-pot synthesis through transamidation and subsequent dehydration. Recyclability of chitosan was demonstrated, with quantitative yields of products obtained without any loss of catalytic activity. the Partner Organisations 2014.

Direct Coupling of Functionalized Organolithium Compounds with Aryl and Vinyl Halides

The reaction between β- and γ-nitrogen-functionalized and γ- and ε-oxygen-functionalized organolithium compounds 3, 4, 30-32 and different aromatic, heteroaromatic, and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 5-26 and alcohols 33-37.Symmetrical and mixed products of double coupling 38-40 were also prepared from 1,4-diiodobenzene.The formation of alkyl halides as intermediates has been verified.Aryl or vinyl halides giving rise to unstable aryl or vinyllithium reagents were unsuccessful in the coupling reaction.