3189-06-8Relevant academic research and scientific papers
Preparation method for 7-azaindole
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Paragraph 0022-0030, (2019/01/08)
The invention discloses a preparation method for 7-azaindole, and belongs to technical field of the medicinal chemistry synthesis. The preparation method comprises the following steps: using a compound I, namely 2-amino-3-methylpyridine and N-methylformanilide, to perform an addition elimination reaction under the action of a dehydrating agent, to obtain a compound II; performing intramolecular ring closure on the compound II under the action of strong base, to obtain a target compound III. The preparation method is capable of acquiring the target product through two-step synthesis only. The method is simple in post-treatment, less in side reaction, high in yield, and in comply with requirements of industrial production. (The formula is shown in the description.).
