318987-58-5Relevant articles and documents
Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors IV. A series of new derivatives containing a spiro[5H-oxazolo[3,2-a]pyrazine-2(3H),4′-piperidin]-5-one skeleton
Nishida, Hidemitsu,Mukaihira, Takafumi,Saitoh, Fumihiko,Harada, Kousuke,Fukui, Miyuki,Matsusue, Tomokazu,Okamoto, Atsushi,Hosaka, Yoshitaka,Matsumoto, Miwa,Shiromizu, Ikuya,Ohnishi, Shuhei,Mochizuki, Hidenori
, p. 406 - 412 (2007/10/03)
In the course of development of factor Xa (FXa) inhibitor in an investigation involving the synthesis of 1-arylsulfonyl-3-piperazinone derivatives, we found new compounds containing a unique spiro skeleton. Among such compounds, (-)-7-[(6-chloro-2-naphtha
TRICYCLIC COMPOUNDS HAVING SPIRO UNION
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Example 25, (2008/06/13)
This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally