3190-04-3Relevant academic research and scientific papers
A New, Short, and Stereocontrolled Synthesis of C2-Symmetric 1,2-Diamines
Vemula, Rajender,Wilde, Nathan C.,Goreti, Rajendar,Corey
, p. 3883 - 3886 (2017/07/26)
The previously unknown 5-spirocyclohexylisoimidazole has been made efficiently and simply by reaction of ammonia, glyoxal hydrate, and cyclohexanone. It is a very useful precursor for the diastereocontrolled synthesis of many C2-symmetric 1,2-diamines, a class which is important for the generation of a variety of C2-symmetric reagents and catalysts for enantioselective synthesis.
Diversity-Oriented Synthesis of a Library of Star-Shaped 2H-Imidazolines
Yu, Xuepu,Guttenberger, Nikolaus,Fuchs, Elisabeth,Peters, Martin,Weber, Hansj?rg,Breinbauer, Rolf
, p. 682 - 690 (2015/11/17)
A library of star-shaped 2H-imidazolines has been synthesized via Debus-Radziszewski condensation from 1,2-diketones and ketone starting materials. Selective reduction of one imine group of the 2H-imidazole intermediate with LiAlH4 or catalytic flow hydrogenation furnished 2H-imidazolines, which could be conveniently diversified by reacting the amine N with electrophiles, resulting in a set of 21 amide-, carbamate-, urea-, and allylamine-containing products. In total, five points of diversification could be used, which allow the production of a set of functionally diverse compounds. The synthesis of acylated 2H-imidazolidines resulted in intrinsically labile compounds, which spontaneously degraded to acyclic derivatives, as shown for the reaction of 2H-imidazolidine with hexylisocyanate.
Comparison of Birch with electrochemical reduction of 2,3-diphenyl-1,4- diazaspiro[4.5]deca-1,3-diene
Zhou, Yan,Andreou, Anna,Biktagirov, Eldar,Eames, Jason,Wadhawan, Jay
experimental part, p. 1493 - 1497 (2011/11/29)
Reduction of 2,3-diphenyl-1,4-diazaspiro[4.5]deca-1,3-diene is investigated both voltammetrically (glassy-carbon electrode, 20 °C, non-aqueous- solvents) and using dissolving-metals (sodium, -78 °C, tetrahydrofuran (THF)/NH3(l)). Remarkably, el
Convenient Routes to Symmetrical Benzils and Chiral 1,2-Diaryl-1,2-diaminoethanes, Useful Controllers and Probes for Enantioselective Synthesis
Corey, E. J.,Lee, Duck-Hyung,Sarshar, Sepehr
, p. 3 - 6 (2007/10/02)
Pathways for the diastereoselective preparation of chiral 1,2-diaryl-1,2-diaminoethanes from ArCOOH, ArCHO or ArBr are described.
