319012-18-5Relevant academic research and scientific papers
Inhibitors of hepatitis C virus NS3·4A protease 1. Non-charged tetrapeptide variants
Perni, Robert B.,Britt, Shawn D.,Court, John C.,Courtney, Lawrence F.,Deininger, David D.,Farmer, Luc J.,Gates, Cynthia A.,Harbeson, Scott L.,Kim, Joseph L.,Landro, James A.,Levin, Rhonda B.,Luong, Yu-Ping,O'Malley, Ethan T.,Pitlik, Janos,Rao, B. Govinda,Schairer, Wayne C.,Thomson, John A.,Tung, Roger D.,Van Drie, John H.,Wei, Yunyi
, p. 4059 - 4063 (2003)
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.
